基于间充质干细胞的矽肺治疗研究现状  

Advances on mesenchymal stem cell based therapy for silicosis

作　　者：刘浪 贺瑶瑶 田青 周东海[1] LIU Lang;HE Yaoyao;TIAN Qing;ZHOU Donghai(Institute of Public Health Monitoring and Evaluation,Guizhou Provincial Center for Disease Control and Prevention,Guiyang,Guizhou 550000,China)

机构地区：[1]贵州省疾病预防控制中心公共卫生监测评价研究所,贵州贵阳550000

出　　处：《环境与职业医学》2021年第1期99-103,共5页Journal of Environmental and Occupational Medicine

摘　　要：尘肺病在世界范围内都是最为严重的职业病,其中又以矽肺为主。目前对于矽肺尚无特效的治疗手段,现有的治疗方法也仅能对矽肺患者症状有一定缓解,在延缓肺部纤维化方面发挥一定作用,且治疗效果不尽人意。干细胞疗法作为一种安全有效、无免疫排斥、适用范围广的新兴方法,在矽肺的治疗中已有大量实验研究。本文介绍了近年来间充质干细胞在矽肺模型中的实验研究进展,详细叙述了矽尘对肺组织的损伤机制及间充质干细胞在矽肺模型中的保护机制,包括抑制炎症因子、减少纤维化相关细胞因子的分泌、抑制细胞凋亡、抑制内皮-间质转化、调节自噬等,并指出了目前间充质干细胞治疗矽肺存在的问题及未来的发展方向。Pneumoconiosis is the most serious occupational disease in the world.Among all the pneumoconiosis,silicosis accounts for the majority of cases.At present,there are no specific treatments,and available therapies for silicosis can only alleviate symptoms and delay pulmonary fibrosis,producing effects less than satisfactory.Stem cell therapy as a safe and effective new method featuring no immune rejection and wide application has been studied in many diseases,including silicosis.This paper reviewed the research of mesenchymal stem cells in silicosis model in recent years.The potential mechanisms of lung injury induced by silica and the proposed protective mechanism of mesenchymal stem cells in silicosis model were described,including inhibiting inflammatory factors,apoptosis,or endothelial mesenchymal transition,reducing the level of pro-fibrosis cytokines,and regulating autophagy.Problems and future development directions of mesenchymal stem cells in the treatment of silicosis were also discussed.

关 键 词：矽肺 治疗 纤维化 间充质干细胞 

分 类 号：R13[医药卫生—劳动卫生]