糖尿病住院患者并发肺结核的临床特征分析  

Clinical characteristics of pulmonary tuberculosis in hospitalized patients with diabetes mellitus

作　　者：曾剑锋[1] 杨敏 唐芳[2] 朱惠敏[2] 陈涛[1] 邓国防[1] 张培泽[1] ZENG Jian-feng;YANG Min;TANG Fang;ZHU Hui-min;CHEN Tao;DENG Guo-fang;ZHANG Pei-ze(National Clinical Research Center for Infectious Disease,Department of Pulmonary Medicine and Tuberculosis,the Third People’s Hospital of Shenzhen,Shenzhen 518112,China)

机构地区：[1]国家感染性疾病临床医学研究中心,深圳市第三人民医院肺病科,518112 [2]国家感染性疾病临床医学研究中心,深圳市第三人民医院内二科,518112

出　　处：《中国防痨杂志》2021年第1期31-35,共5页Chinese Journal of Antituberculosis

基　　金：“十三五”国家科技重大专项(2018ZX10715004-002-007)。

摘　　要：目的了解糖尿病(包括1型、2型糖尿病患者)住院患者并发肺结核的发病率,以及对结核病活动状态的相关性进行分析。方法回顾性分析2018年1月至2019年12月我院患糖尿病住院的2648例患者常规胸部影像学检查资料及临床资料,计算糖尿病患者并发肺结核的发病率,比较活动性与非活动性肺结核患者的基本情况,以及糖化血红蛋白(HbA1c)水平、糖尿病治疗情况。结果 2648例糖尿病患者中,2585例患者无肺结核证据,占97.62%(2585/2648);31例患者并发活动性肺结核,占1.17%(31/2648);32例患者并发非活动性肺结核,占1.21%(32/2648);活动性、非活动性肺结核均以男性为主,分别占90.32%(28/31)、84.38%(27/32);活动性肺结核患者的平均年龄为(51.16±13.06)岁,非活动性肺结核患者的平均年龄为(61.78±12.88)岁,二组比较差异有统计学意义(t=-3.236,P=0.002);活动性肺结核患者的HbA1c水平检测平均为(9.18±2.85)%,非活动性肺结核患者平均为(8.05±1.69)%,二组比较差异无统计学意义(t=1.884,P=0.070)。结论糖尿病住院患者并发肺结核的比例高,以男性多见,应重视糖尿病住院患者的肺结核筛查和随访;血糖控制水平与糖尿病患者肺结核活动状态的相关性尚需进一步证实。Objective To investigate the incidence rate of pulmonary tuberculosis(TB)in hospitalized patients with diabetes mellitus(including type 1 and type 2 diabetes)and analyze the correlation between the activity of TB and the incidence of tuberculosis. Methods We retrospectively reviewed the routine chest imaging and clinical data of 2648 patients with diabetes in our hospital from January 2018 to December 2019.We then calculated the incidence rate of pulmonary tuberculosis in diabetic patients.The basic characteristics,the level of glycosylated hemoglobin and the status of diabetes treatment were compared between active tuberculosis group and inactive tuberculosis group. Results Of the 2648 patients with diabetes,2585 patients had no evidence of tuberculosis,accounting for 97.62%(2585/2648);31 patients complicated with active tuberculosis,accounting for 1.17%(31/2648);32 patients complicated with inactive tuberculosis,accounting for 1.21%(32/2648). Active tuberculosis and inactive tuberculosis were mainly male,accounting for 90.32%(28/31)and 84.38%(27/32)respectively.The average age of active tuberculosis patients was(51.16±13.06)years old,of inactive tuberculosis patients was(61.78±12.88)years old.The difference between the two groups was statistically significant(t=-3.236,P=0.002).The average glycosylated hemoglobin of patients with active tuberculosis was(9.18±2.85)%,of patients with inactive tuberculosis was(8.05±1.69)%.There was no significant difference between the two groups(t=1.884,P=0.070). Conclusion Diabetes inpatients have a high proportion of concurrent tuberculosis,most of them are male.We should pay attention to the screening and follow-up of pulmonary tuberculosis in diabetic inpatients;the correlation between blood glucose control level and tuberculosis activity of diabetic patients needs to be further confirmed.

关 键 词：糖尿病 结核 肺 共病现象 疾病特征 发病率 数据说明 统计 回顾性研究 

分 类 号：R587.2[医药卫生—内分泌] R521[医药卫生—内科学]