噻托溴铵联合N-乙酰半胱氨酸治疗慢性阻塞性肺疾病的临床效果  

Clinical effect of tiotropium bromide combined with N-acetylcysteine in the treatment of chronic obstructive pulmonary disease

作　　者：邵健[1] SHAO Jian(Department of Pharmacy,Zhangjiagang First People’s Hospital,Jiangsu Province,Zhangjiagang 215600,China)

机构地区：[1]江苏省张家港市第一人民医院药学部,215600

出　　处：《临床合理用药杂志》2021年第1期30-32,共3页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察噻托溴铵联合N-乙酰半胱氨酸治疗慢性阻塞性肺疾病的临床效果。方法选取2019年1-10月江苏省张家港市第一人民医院收治的慢性阻塞性肺疾病患者58例采用随机数字表法分为观察组和对照组各29例。对照组接受噻托溴铵治疗,观察组接受噻托溴铵联合N-Z酰半胱氨酸治疗,2组均开展呼吸训练。比较2组临床疗效,治疗前后血气状况[动脉血氧分压(PaO_(2))、血氧饱和度(SpO_(2))、动脉血二氧化碳分压(PaCO_(2))]、肺功能[1 s用力呼气容积(FEV_(1))、FEV_(1)/用力肺活量(FVC)、FEV_(1)占预计值的百分比]不良反应。结果治疗后,2组PaO_(2)、SpO_(2)均升高PaCO_(2)均下降且观察组改善幅度大于对照组(P<0.01);治疗后2组FEV_(1)、FEV_(1)/FVC、FEV_(1)占预计值的百分比均升高且观察组高于对照组(P<0.05);观察组不良反应总发生率为17.24%,对照组不良反应总发生率为13.79%2组比较差异无统计学意义(χ^(2)=0.132,P=0.717)。结论噻托溴铵联合N-乙酰半胱氨酸治疗慢性阻塞性肺疾病可更明显改善患者血气状况与肺功能且治疗安全性高,值得推广。Objective To observe the clinical effect of tiotropium bromide combined with N-acetylcysteine in the treatment of chronic obstructive pulmonary disease.Methods Fifty-eight patients with chronic obstructive pulmonary disease admitted to Zhangjiagang First People’s Hospital,Jiangsu Province from January to October 2019 were selected.They were divided into observation group and control group by random number table method,each of 29 cases.The control group received tiotropium bromide treatment,the observation group received tiotropium bromide combined with N-acetylcysteine treatment,and both groups received respiratory training.Compared the clinical efficacy,before and after treatment arterial blood oxygen partial pressure(PaO_(2)),blood oxygen saturation(SpO_(2)),arterial carbon dioxide partial pressure(PaCO_(2)),1 s forced expiratory volume(FEV_(1)),FEV_(1)/forced vital capacity(FVC),FEV_(1)as a percentage of the predicted value,adverse reactions between the two groups.Results After treatment,two groups of PaO_(2),SpO_(2)levels were elevated/PaCO_(2)level decreased,and the observation group improved amplitude was greater than the control group(P<0.01).After treatment,two groups of FEV_(1),FEV_(1)/FVC,FEV_(1)accounts for the percentage of the estimated value were increased,and the observation group was higher than the control group(P<0.05).Observation group the incidence of adverse reactions to the total was 17.24%,control group in the incidence of adverse reactions to the total was 13.79%,there was no statistically significant difference comparing between the two groups(χ^(2)=0.132,P=0.717).Conclusion Tiotropium bromide combined with N-acetylcysteine in the treatment of chronic obstructive pulmonary disease can significantly improve the blood gas status and lung function,and the treatment is safe and worthy of promotion.

关 键 词：慢性阻塞性肺疾病 噻托溴铵 N-乙酰半胱氨酸 

分 类 号：R563.9[医药卫生—呼吸系统]