Rh阴性孕妇应用抗D免疫球蛋白的相关问题  

Few points on anti-D immunoglobulin administration in Rh-negative pregnant women

作　　者：孙笑[1] 孙瑜[1] 韩萌萌 Sun Xiao;Sun Yu;Han Mengmeng(Department of Gynecology and Obstetrics,Peking University First Hospital,Beijing 100034,China;Department of Obstetrics,Haidian Maternal&Child Health Hospital,Beijing 100080,China)

机构地区：[1]北京大学第一医院妇产科,100034 [2]北京市海淀区妇幼保健院产科,100080

出　　处：《中华围产医学杂志》2021年第2期152-154,共3页Chinese Journal of Perinatal Medicine

摘　　要：抗D免疫球蛋白预防RhD同种免疫的效果较好,不良反应轻且发生率很低。但我国至今尚无此方面的临床规范或指南。现结合国内外相关文献,对抗D免疫球蛋白的作用机制、剂量效应与安全性、产前抗体筛查的时机与合理性、产前常规抗D免疫球蛋白应用的合理时机与剂量、产前需要额外给予抗D免疫球蛋白的情况以及产后预防等关键问题进行总结。Anti-D immunoglobulin effectively prevents RhD alloimmunity and has a low incidence of adverse reactions,which are generally mild.A consensus is yet to be reached regarding the clinical norms in China.We provide an overview of anti-D immunoglobulin in preventing RhD alloimmunity,including its mechanism of action,dose-effect,and safety,the timing and rationality of prenatal antibody screening,the timing and dosage of routine prenatal administration of anti-D immunoglobulin,as well as the prenatal indications for an additional dosage of anti-D immunoglobulin and postpartum prevention based on evidence from both domestic and abroad.

关 键 词：Rho(D)免疫球蛋白 Rh同种免疫 妊娠 产前保健 产后保健 

分 类 号：R714.5[医药卫生—妇产科学]