淋舒汤联合左氧氟沙星治疗以下尿路症状为主的ⅢA型前列腺炎湿热下注证的疗效观察  

Linshu Decoction combined with levofloxacin for lower urinary tract symptoms in patients with type ⅢA prostatitis

作　　者：秦远[1,2] 宋宁宏 叶和松[2] 唐龙龙 杨明 龚闻涛 何麒 张炜 QIN Yuan;SONG Ning-hong;YE He-song;TANG Long-long;YANG Ming;GONG Wen-tao;HE Qi;ZHANG Wei(Department of Urology,The First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China;Department of Urology,The Second Affiliated Hospital of Nanjing University of Chinese Medicine/The Second Jiangsu Provincial Hospital of Traditional Chinese Medicine,Nanjing,Jiangsu 210017,China)

机构地区：[1]南京医科大学第一附属医院泌尿外科,江苏南京210029 [2]南京中医药大学第二附属医院/江苏省第二中医院泌尿外科,江苏南京210017

出　　处：《中华男科学杂志》2020年第11期1025-1029,共5页National Journal of Andrology

基　　金：南京中医药大学第二附属医院院内科研基金项目(SEZJJP2018021)。

摘　　要：目的:探究淋舒汤联合左氧氟沙星治疗以下尿路症状为主的ⅢA型前列腺炎湿热下注证的疗效。方法:将124例以下尿路症状为主的ⅢA型前列腺炎湿热下注证患者随机分为试验组和对照组,试验组采取淋舒汤(每日水煎服用1剂)联合左氧氟沙星片(每次0.1 g,每日2次)口服治疗,对照组采取左氧氟沙星片(每次0.1 g,每日2次)口服治疗,疗程皆为4周。治疗前及治疗4周后进行NIH-CPSI评分、中医症候评分(TCM)、前列腺按摩液中WBC计数检查和尿流率检测进行疗效评价。结果:最终纳入115例患者。治疗4周后,试验组NIH-CPSI评分为(14.57±3.87)分,TCM为(6.35±1.27)分,前列腺按摩液中WBC计数为(7.35±4.52)个/HP,均显著低于对照组(20.12±3.45)分、(10.72±1.72)分、(9.87±5.87)个/HP(P均<0.05)。两组患者治疗后的最大尿流率及平均尿流率均增加,但只有试验组治疗前后有统计学差异。结论:与单用左氧氟沙星相比,淋舒汤联合左氧氟沙星可以更加有效治疗以下尿路症状为主的ⅢA型前列腺炎湿热下注证。Objective:To investigate the effect of Linshu Decoction(LSD)combined with levofloxacin in the treatment of lower urinary tract symptoms in patients with type ⅢA prostatitis.Methods:We randomly divided 124 type ⅢA prostatitis patients with lower urinary tract symptoms into an experimental and a control group,the former treated orally with LSD(1 dose bid)combined with levofloxacin tablets(0.1 g bid),and the latter with levofloxacin tablets only(0.1 g bid).Before and after 4 weeks of medication,we obtained the NIH-CPSI,Traditional Chinese Medicine symptoms(TCM)scores,white blood cell(WBC)count in EPS and the results of uroflowmetry from the patients and compared them between the two groups.Results:Finally 115 of the patients were included in this study.After 4 weeks of treatment,the patients of the experimental group,compared with the controls,showed significantly decreased NIH-CPSI(14.57±3.87 vs 20.12±3.45,P<0.05),TCM scores(6.35±1.27 vs 10.72±1.72,P<0.05)and WBC count in EPS([7.35±4.52]vs[9.87±5.87]n/HP,P<0.05).In comparison with baseline,the maximum urinary flow rate(Qmax)and average urinary flow rate(Qave)were increased in both of the two groups after medication,with statistically significant difference only in the experimental group(P<0.05).Conclusion:Linshu Decoction combined with levofloxacin is more effective than levofloxacin alone in the treatment of lower urinary tract symptoms in patients with type ⅢA prostatitis.

关 键 词：淋舒汤 左氧氟沙星 下尿路症状 ⅢA型前列腺炎 

分 类 号：R697.33[医药卫生—泌尿科学]