高频皮肤超声在光动力治疗儿童鲜红斑痣的疗效评估  

A Clinical study on evaluating the treatment effect of port-wine stains in children by high frequency ultrasound

作　　者：张建[1] 甘立强[1] 王华[1] 罗晓燕[1] 谭春花[1] 倪思利[1] Zhang Jian;Gan Liqiang;Wang Hua;Luo Xiaoyan;Tan Chunhua;Ni Sili(Department of Dermatology,Children’s Hospital of Chongqing Medical UniversityChongqing 400014,China)

机构地区：[1]重庆医科大学附属儿童医院皮肤科<儿童发育疾病研究教育部重点实验室><国家儿童健康与疾病临床医学研究中心><儿童发育重大疾病国家国际科技合作基地><儿科学重庆市重点实验室>,重庆400014

出　　处：《医药前沿》2020年第32期22-24,共3页Journal of Frontiers of Medicine

基　　金：2019年重庆市科卫联合医学科研项目(面上项目)(2019MSXM049)。

摘　　要：目的:探讨高频皮肤超声应用于儿童鲜红斑痣患者光动力治疗后疗效评估的可行性。方法:选取2018年6月—2019年6月我院门诊确诊的头面部有鲜红斑痣皮损并接受光动力治疗的患儿60例。所有患儿在接受光动力治疗前采用了高频皮肤超声对相关皮损部位的皮肤厚度值进行测量,并在治疗后,用同样的方式测量病变对侧正常皮肤的相关厚度值。在患儿接受了一个完整疗程(3次治疗)治疗后,用传统的方法即治疗前、后用单反数码照片来评估皮损的面积及颜色消退情况,分为基愈,显效、有效、无效四组。然后对这四组治疗前、治疗后的皮损以及对侧正常的皮肤的厚度进行分析。结果:各组间正常的皮肤厚度比较无显著差异(P>0.05)。对治疗前各组间的皮损厚度进行比较,基愈组、显效组较有效组、无效组厚度薄。基愈组、显效组分别与有效组,无效组的皮肤厚度比较显示均有统计学差异(P<0.05)。鲜红斑痣治疗后,基愈组、显效组、有效组皮损厚度均较治疗前变薄。基愈组,显效组,有效组治疗前、后各组皮损厚度改变均有统计学差异(P<0.05)。无效组治疗前、后皮肤厚度的改变不显著,显示治疗前、治疗后皮肤厚度改变没有统计学差异(P>0.05)。结论:高频超声技术能对正常的皮肤、鲜红斑痣病变的皮肤进行皮肤厚度的精确测量,通过高频超声对头面部鲜红斑痣病变光动力治疗前后的皮肤厚度进行精确测量可作为鲜红斑痣患儿术前进行疗效预判、术后临床疗效评估的重要客观评价参考。Objective To investigate the feasibility of assessment method using high frequency ultrasound for evaluating treatment effect of port-wine stains by photodynamic therapy in children.Methods Select from June 2018 to June 201960 patients random patients diagnosed with port-wine stains,having craniofacial skin lesion,receiving photodynamic therapy were selected.High frequency ultrasound(DermaLab Combo,Cortex,Denmark)was used to measure skin thickness before and after a course of photodynamic treatment.Traditional method was used to evaluated the treatment effect.And according to the evaluating Results,patients were divided into 4 groups,including curative group,excellent group,effective group and invalid group.The Results of high frequency ultrasound measurement of each group were analyzed.Results There is no statistical significance in skin thickness of health skin between each group(P>0.05).The skin thickness before treatment in curative group and excellent group are thiner than that in effective group and invalid group.And there is statisfical significance between curative group,excellent group and effective group,invalid group respectively(P<0.05).The skin thickness gets thiner of curative group,excellent group and effective group after treatment.There is statisfical significance in the changes of skin thickness in curative group,excellent group and effective group(P<0.05).And there is no statisfical significance in the changes of skin thickness in invalid group(P>0.05).Conclusion The skin thickness of lesion and health skin in children with port-wine stains can be measured by high frequency ultrasound,and high frequency ultrasound can be used to evaluate the photodynamic therapy effect of port-wine stains in children.

关 键 词：高频超声 儿童 鲜红斑痣 光动力 疗效评估 

分 类 号：R445.1[医药卫生—影像医学与核医学]