假单胞菌代谢产物藤黄绿菌素化学结构、生物合成途径、调控机制及应用研究进展  

Research Progress in Chemical Structure,Biosynthesis,Regulation and Applications of Pseudomonas Metabolite Pyoluteorin

作　　者：崔莹 宋凯 何亚文[1] CUI Ying;SONG Kai;HE Yawen(State Key Laboratory of Microbial Metabolism/Joint International Research Laboratory of Metabolic and Developmental Sciences/School of Life Sciences&Biotechnology,Shanghai Jiao Tong University,Shanghai 200240,China)

机构地区：[1]上海交通大学生命科学技术学院/微生物代谢国家重点实验室/教育部代谢与发育科学国际合作联合实验室,上海200240

出　　处：《中国生物防治学报》2021年第1期52-59,共8页Chinese Journal of Biological Control

基　　金：国家重点研发计划(2018YFA0901900)。

摘　　要：藤黄绿菌素(pyoluteorin,Plt)是假单胞菌产生的次级代谢产物,具有广谱抑菌活性。本文系统介绍了Plt产生菌、化学结构、生物合成途径及其调控机制等方面的研究进展。在此基础上,总结了构建高产Plt工程菌株的策略和成果。最后,展望了Plt成为新型代谢产物农药的潜力和未来的研究方向。Pyoluteorin(Plt)is one of the secondary metabolites produced by Pseudomonas spp.and has a broad spectrum of antibiotic activity.In this review,Plt producing strains,chemical structure,biosynthesis and regulatory mechanisms were introduced.The strategies and achievements in constructing high Plt yield strains were then summarized.Finally,the potential of Plt as a new metabolite biopesticide and future work in this field were discussed and prospected.

关 键 词：假单胞菌 藤黄绿菌素 生物合成 调控网络 代谢产物农药 

分 类 号：S476[农业科学—农业昆虫与害虫防治]