加减圣愈汤改善晚期结肠癌患者肿瘤化疗相关性中度贫血的临床研究  

Clinical Study on Modified Shengyu Decoction(加减圣愈汤)in Improving Moderate Anemia Related to Tumor Chemotherapy in Patients with Advanced Colon Cancer

作　　者：王若进[1] 李绍旦[1] 王朴 崔艺馨[1] 杨青青[1] 吴煜[3] WANG Ruo-jin;LI Shao-dan;WANG Pu;CUI Yi-xin;YANG Qing-qing;WU Yu(General Hospital of Chinese People's Liberation Army,Beijing 100853,China;Community Health Service Center of Zhanlan Road,Beijing 100037,China;Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China)

机构地区：[1]解放军总医院,北京100853 [2]北京市西城区展览路社区卫生服务中心,北京100037 [3]中国中医科学院西苑医院,北京100091

出　　处：《中医药导报》2021年第2期49-52,59,共5页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：北京市科技计划项目(D161100005116002)。

摘　　要：目的:观察加减圣愈汤对于改善晚期结肠癌患者肿瘤化疗相关性中度贫血的临床疗效。方法:选取晚期结肠癌伴肿瘤化疗相关性中度贫血患者80例,随机分为治疗组和对照组各40例,治疗组患者给予加减圣愈汤治疗,对照组患者给予重组人促红素注射液及多糖铁复合物胶囊治疗,以21 d为1个周期,治疗4个周期。分别对比治疗前、治疗2周期及治疗4周期两组患者的血红蛋白、红细胞计数、血细胞压积、中医证候评分及不良反应。结果:治疗2周期,两组患者临床疗效比较,差异无统计学意义(P>0.05);治疗4周期,治疗组患者临床疗效优于对照组,差异有统计学意义(P<0.05);治疗2周期,两组患者血红蛋白、红细胞计数、血细胞压积、中医证候评分比较,差异无统计学意义(P>0.05);治疗4周期,治疗组患者各项指标均优于对照组(P<0.05);组内比较,治疗组患者治疗4周期的指标变化优于治疗2周期(P<0.05),对照组患者治疗4周期与治疗2周期比较,差异无统计学意义(P>0.05)。结论:加减圣愈汤能明显改善晚期结肠癌患者肿瘤化疗相关性中度贫血。Objective:To observe the clinical efficacy of Modified Shengyu Decoction for improving tumor chemotherapy-related moderate anemia in patients with advanced colon cancer.Methods:A total of 80 patients with advanced colon cancer and tumor chemotherapy-related moderate anemia were randomly divided into treatment group and control group,with 40 cases in each group.The patients in the treatment group were treated with Modified Shengyu Decoction,and the patients in the control group were treated with recombinant human erythropoietin injection and polysaccharide iron complex capsules,with 21 days as a cycle and 4 cycles.The hemoglobin,red blood cell count,hematocrit,TCM syndrome score and adverse reactions of the two groups of patients before treatment,treatment 2 cycles and treatment 4 cycles were compared.Results:There was no significant difference in clinical efficacy between the two groups after 2 cycles of treatment(P>0.05).The clinical efficacy of the treatment group was better than that of the control group after 4 cycles of treatment(P<0.05).There was no significant difference in hemoglobin,red blood cell count,hematocrit and TCM syndrome score between the two groups after 2 cycles of treatment(P>0.05).The indexes of the treatment group were better than those of the control group after 4 cycles of treatment(P<0.05).Within group comparison,the index change of patients in the treatment group for 4 cycles were better than those for 2 cycles(P<0.05),and there was no statistically significant difference between the the 2 cycles and 4 cycles of treatment in the control group(P>0.05).Conclusion:Modified Shengyu Decoction can significantly improve tumor chemotherapy-related moderate anemia in patients with advanced colon cancer.

关 键 词：结肠癌 晚期 肿瘤化疗相关性贫血 中度贫血 加减圣愈汤 

分 类 号：R273[医药卫生—中西医结合]