间充质干细胞治疗骨关节炎软骨损伤:作用、应用与问题  

Mesenchymal stem cells in the treatment of cartilage damage in osteoarthritis:role,application,and problem

作　　者：王新伟 赵英杰[1] 常艳[1] 魏伟[1] Wang Xinwei;Zhao Yingjie;Chang Yan;Wei Wei(Institute of Clinical Pharmacology,Anhui Medical University,Key Laboratory of Antiinflammatory and Immune Medicine,Ministry of Education,Anhui University Collaborative Innovation Center for Antiinflammatory and Immune Drugs,Hefei 230032,Anhui Province,China)

机构地区：[1]安徽医科大学临床药理研究所,抗炎免疫药物教育部重点实验室,安徽省高校抗炎免疫药物协同创新中心,安徽省合肥市230032

出　　处：《中国组织工程研究》2021年第31期5053-5058,共6页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金面上项目(81573443,81673444),项目负责人:常艳;安徽省自然科学杰出青年基金(170808J10),项目负责人:常艳;2016年高校优秀青年人才支持计划重点项目(gxyqZD2016043),项目负责人:常艳。

摘　　要：背景:间充质干细胞来源广泛、易于分离培养,并且具有多向分化、组织修复、抗炎和免疫调节功能,为治疗骨关节炎软骨损伤提供新的途径。目的:对间充质干细胞治疗骨关节炎软骨损伤的应用和研究方面作一综述。方法:由第一作者以“osteoarthritis,cartilage damage,mesenchymal stem cell,treatment”为英文关键词,以“间充质干细胞,骨关节炎,软骨损伤,治疗”为中文关键词,检索2000至2020年期间收录在PubMed和中国知网数据库中的相关文献,排除与文章研究目的无关及重复性的文献,对纳入符合标准的50篇文献进行综述。结果与结论:①组织工程方法将间充质干细胞的多向分化功能和生物支架材料的特性结合,能够更好地促进受损软骨的修复,已在基础研究和临床研究上取得了众多成果;②间充质干细胞与溶媒联用关节腔注射可以充分发挥间充质干细胞的治疗作用,而且可以将间充质干细胞的优点扩大;③间充质干细胞外泌体治疗骨关节软骨损伤目前还停留在临床前动物研究阶段,但有希望成为骨关节炎软骨损伤治疗的新手段。BACKGROUND:Mesenchymal stem cells have a wide range of sources and are easy to be isolated and cultured.It also has the functions of multidirectional differentiation,tissue repair,anti-inflammatory and immune regulation,which provides a new approach for the treatment of articular cartilage injury.OBJECTIVE:To review the application and research of mesenchymal stem cells in the treatment of osteoarthritis cartilage damage.METHODS:Using“osteoarthritis,cartilage damage,mesenchymal stem cell,treatment”as the English and Chinese keywords,the first author retrieved the included in PubMed and CNKI databases from 2000 to 2020.After excluding articles that were not relevant and repetitive for the purpose of the article,fifty articles were included for review in the end.RESULTS AND CONCLUSION:(1)Tissue engineering methods combined the multi-differentiation function of mesenchymal stem cells with the characteristics of bioscaffold materials can better promote the repair of damaged cartilage,and has made many achievements in basic research and clinical research.(2)Joint injection of mesenchymal stem cells with the solvent can exert the therapeutic effect and expand the advantages of mesenchymal stem cells.(3)Mesenchymal stem cell exosome for the therapy of osteoarthritis cartilage damage is still in the basic stage,which will become the developmental trend of osteoarthritis cartilage damage treatment.

关 键 词：干细胞 间充质干细胞 骨关节炎 软骨损伤 治疗 组织工程 综述 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学]