骨形态发生蛋白-2(BMP2)基因的生理功能和信号通路研究进展  

Research Progress on Physiological Function and Single Pathway of Bone Morphogenetic Protein-2(BMP2)Gene

作　　者：费晓娟 金美林 卢曾奎 狄冉[1] 魏彩虹[1] FEI Xiaojuan;JIN Meilin;LU Zengkui;DI Ran;WEI Caihong(Institute of Animal Science,Chinese Academy of Agricultural Sciences,Beijing 100193,China;Lanzhou Institute of Husbandry and Pharmaceutical Sciences,Chinese Academy of Agricultural Sciences,Gansu Lanzhou 730050,China)

机构地区：[1]中国农业科学院北京畜牧兽医研究所,北京100193 [2]中国农业科学院兰州畜牧与兽药研究所,甘肃兰州730050

出　　处：《中国畜牧杂志》2021年第3期1-7,共7页Chinese Journal of Animal Science

基　　金：国家肉羊产业技术体系项目(CARS-38)。

摘　　要：骨形态发生蛋白-2(BMP-2)是转化生长因子β(TGF-β)超家族的成员。BMP2参与骨形成、生长发育、脂肪沉积和癌症发生等多个生物学过程。BMP2与绵羊尾部脂肪沉积相关,是调控绵羊尾型发育的候选基因。本研究主要介绍了BMP2基因的发现与结构、表达、生理功能和参与信号通路的研究进展,为BMP2基因的研究提供理论基础。Bone morphogenetic protein-2(BMP2)is a member of the transforming growth factor-β(TGF-β)superfamily.BMP2 is involved in many biological processes such as bone formation,growth and development,fat metabolism,and the occurrence of cancer.BMP2 is associated with fat deposition in the tail of sheep which can be a candidate gene for regulating the development of sheep tail.This review introduces the discovery,structure,expression,physiological function,single pathway research progress of BMP2 gene.This paper provides a theoretical basis for the research of BMP2 gene.

关 键 词：BMP2基因 结构和表达 生理功能 信号通路 

分 类 号：S826.2[农业科学—畜牧学]