IRGM/Irgm1调节自噬和凋亡在炎症性疾病中的研究进展  

Research Progress of Role of IRGM/Irgm1 in Regulating Autophagy and Apoptosis in Inflammatory Diseases

作　　者：孙松 郝欣然 邹小乙 万鑫[1,2] 张芳妮 孙博 于波[1,3] 房绍红[1,3] SUN Song;HAO Xinran;ZOU Xiaoyi;WAN Xin;ZHANG Fangni;SUN Bo;YU Bo;FANG Shaohong(The Key Laboratory of Myocardial Ischemia,Chinese Ministry of Education,Harbin 150086,China;Department of Neurobiology,Harbin Medical University,Harbin 150086,China;Department of Cardiology,the Second Affiliated Hospital of Harbin Medical University,Harbin 150086,China)

机构地区：[1]心肌缺血教育部重点实验室,哈尔滨150086 [2]哈尔滨医科大学神经生物学教研室,哈尔滨150086 [3]哈尔滨医科大学附属第二医院心内科,哈尔滨150086

出　　处：《医学综述》2021年第5期882-888,共7页Medical Recapitulate

基　　金：国家自然科学基金(81870353);国家重点研发计划(2016YFC1301100)。

摘　　要：免疫相关GTP酶(IRG)属于γ干扰素诱导性GTP酶家族成员,在γ干扰素介导的宿主抗感染和炎症免疫中起重要作用。正常情况下,IRGM(人类)/Irgm1(小鼠)表达水平较低,在机体受到感染或炎症刺激时,IRGM/Irgm1可被γ干扰素迅速诱导表达并迁移至细胞吞噬溶酶体膜上。目前人们对IRGM/Irgm1在疾病中的研究主要集中在炎性肠病、神经系统疾病以及肿瘤等疾病中。IRGM/Irgm1可能通过介导细胞自噬和凋亡调控疾病的进展,但具体机制目前尚不明确。IRGM/Irgm1作为细胞自噬与凋亡共同的调节蛋白,对多种疾病的发生、发展和转归起重要作用。The immune related GTPase(IRG)is a member of interferon-γinduced GTPase family,which plays an important role in interferon-γmediated host anti-infection and inflammatory immunity.Under normal conditions,the expression of IRGM(human)/Irgm1(mouse)is low,but when the body is stimulated by infection or inflammation,it can be rapidly induced by interferon-γand transferred to the phagocytic lysosomal membrane.At present,the research of IRGM/Irgm1 in diseases mainly focuses on inflammatory bowel disease,nervous system disease and tumor.It is found that IRGM/Irgm1 may regulate the progress of diseases through mediating cell autophagy and apoptosis,but the specific mechanism is not clear yet.As a common regulatory protein of autophagy and apoptosis,IRGM/Irgm1 plays an important role in the occurrence,development and prognosis of many diseases.

关 键 词：免疫相关GTP酶M 自噬 凋亡 

分 类 号：R392.11[医药卫生—免疫学]