PCP信号通路关键因子VANGL在肿瘤细胞迁移和增殖中的作用研究进展  

The role of VANGL, a key protein of the planar cell polarity signaling, in the migration and proliferation of cancer cells

作　　者：沈书凝 徐步捷(综述) 郝雷雨 朱一超(审校)[3] SHEN Shu-ning;XU Bu-jie;HAO Lei-yu;ZHU Yi-chao(The First Clinical Medical School,Nanjing Medical University,Nanjing 211166,Jiangsu,China;Department of Physiology,Nanjing Medical University,Nanjing 211166,Jiangsu,China;State Key Laboratory of Reproductive Medicine,Nanjing Medical University,Nanjing 211166,Jiangsu,China)

机构地区：[1]南京医科大学第一临床医学院,南京211166 [2]南京医科大学生理学系,南京211166 [3]南京医科大学生殖医学国家重点实验室,南京211166

出　　处：《东南国防医药》2021年第2期164-168,共5页Military Medical Journal of Southeast China

基　　金：国家自然科学基金(82073194);江苏省自然科学基金(BK20181367)。

摘　　要：VANGL是一种四次跨膜蛋白,能感受平面细胞极化(PCP)信号,作为PCP信号通路的关键蛋白发挥信号传导的作用。VANGL参与胚胎期神经管闭合、纤毛排列方向发育等多种胚胎发育、组织器官形成过程。而肿瘤的生长和进展通常涉及胚胎发育相关信号通路的异常再激活,因此许多学者探索了VANGL对肿瘤的影响。文章主要就VANGL的分子结构和生理功能以及VANGL与肿瘤细胞迁移和增殖相关的研究进展进行综述。VANGL is a four-pass transmembrane protein,which is one of the key componentsof the planar cell polarity(PCP)signaling pathway.VANGL is involved in several embryonic development and morphogenetic processes,including neural tube closure,cilia orientation,et al.The onset and metastasis of cancer are usually associated with abnormally reactivation of signaling pathways controlling embryonic development.Therefore,the role of VANGL in cancer is focused.This review summarizes the structure and function of VANGL in cancer.

关 键 词：VANGL 平面细胞极化 肿瘤 迁移 增殖 

分 类 号：G301[文化科学]