新型冠状病毒SARS-CoV-2简介及黑腹果蝇在该病毒研究中的潜在应用  

A brief introduction of SARS-CoV-2 and the potential application of drosophila melanogaster in its research

作　　者：陈笛 蓝晓[1] 蔡华[1] CHEN Di;LAN Xiao;CAI Hua(Sino-French Hoffmann Institute,Guangzhou Medical University,Guanzhou 511436,China)

机构地区：[1]广州医科大学广州霍夫曼免疫研究所,广东广州511436

出　　处：《现代医院》2021年第1期162-164,共3页Modern Hospitals

基　　金：广东省自然科学基金项目(2016A030310278);广州市科技计划项目(201707010030);高等学校学科创新引智基地(111计划(D18010))。

摘　　要：新型冠状病毒(SARS-CoV-2)在全球感染人数已达380多万,目前对该病毒了解还比较匮乏。黑腹果蝇是重要的抗感染研究模型,以此为研究模型发现了Toll等经典的重要的抗感染分子信号通路机制。本文综述了SARSCoV-2病毒以及生命周期和致病性,然后讨论了黑腹果蝇在SARS-CoV-2研究中的潜在应用,为研究SARS-CoV-2调控天然免疫、致病性以及抗病毒药物筛选等方面提供参考。More than 3.8 million people have been infected with SARS-CoV-2.As a newly emerging virus,little information about it is known.Drosophila melanogaster is an important model to investigate microbial infection,leading to some important findings like the role of toll in microbial infection,which was awarded with Nobel Prize in physiology and medicine in2011.In this review,we summarized the lifecycle of SARS-CoV-2 and discussed the potential role of drosophila in investigating SARS-CoV-2 related innate immune response,pathogenesis and antiviral screening.

关 键 词：新型冠状病毒 黑腹果蝇 天然免疫 

分 类 号：Q969[生物学—昆虫学]