溶酶体在新城疫病毒诱导肿瘤细胞凋亡和自噬中的作用  

The role of lysosomes in Newcastle disease virus-induced tumor apoptosis and autophagy

作　　者：金燕 刘开扬 JIN Yan;LIU Kai-yang(Life Science Research Center,Hebei North University,Zhangjiakou 075000,China)

机构地区：[1]河北北方学院生命科学研究中心,张家口075000

出　　处：《中国人兽共患病学报》2021年第2期146-151,共6页Chinese Journal of Zoonoses

基　　金：河北省自然科学基金资助项目(No.H2018405044);河北省教育厅项目(No.Z2020129);河北北方学院青年基金项目(No.QN2020027)。

摘　　要：溶瘤病毒(oncolytic virus,OV)具有对肿瘤细胞选择性杀伤而对正常细胞无影响的特性,在针对肿瘤治疗方面有着巨大的潜力。凋亡与自噬在溶瘤病毒杀伤肿瘤细胞的过程中扮演者重要的角色,而溶酶体与二者有着密切的联系。新城疫病毒(newcastle disease virus,NDV)在感染肿瘤细胞后,溶酶体不仅会触发凋亡和溶酶体细胞死亡途径,而且会抑制细胞发生保护性自噬。因此,了解溶酶体在NDV诱导凋亡和自噬的确切作用可以提高NDV治疗各种癌症的治疗潜力,为今后攻克肿瘤提供理论基础。Oncolytic virus(OV)selectively kills tumor cells but has no effect on normal cells;consequently,it has become a promising cancer treatment.Apoptosis and autophagy play important roles in the killing of tumor cells by OV,and lysosomes are closely involved in these processes.After Newcastle disease virus(NDV)infects tumor cells,lysosomes not only trigger apoptotic and lysosomal cell death pathways,but also inhibit cytoprotective autophagy.Therefore,understanding the exact roles of lysosomes in NDV-induced apoptosis and autophagy may improve the therapeutic potential of NDV in the treatment of various cancers and provide a theoretical basis for overcoming tumors in the future.

关 键 词：溶瘤病毒 新城疫病毒 溶酶体依赖性细胞死亡 细胞凋亡 自噬 

分 类 号：R373[医药卫生—病原生物学]