达格列净联合胰岛素治疗2型糖尿病的效果及其对血糖波动的影响  

Effect of dapagliflozin combined with insulin in the treatment of type 2 diabetes mellitus and its influence on blood glucose fluctuation

作　　者：范慧洁[1] 杨雪[1] 殷璐[1] 孙晓菲[1] 董其娟 Fan Huijie;Yang Xue;Yin Lu;Sun Xiaofei;Dong Qijuan(Department of Endocrinology,Zhengzhou People's Hospital,Zhengzhou 450000,Chin)

机构地区：[1]郑州人民医院内分泌科,450000

出　　处：《中国实用医刊》2021年第2期99-102,共4页Chinese Journal of Practical Medicine

基　　金：2018年河南省科技攻关项目(182102310224)。

摘　　要：目的探讨达格列净联合胰岛素治疗2型糖尿病的效果及其对血糖波动的影响。方法抽取2018年8月至2020年7月郑州人民医院收治的94例2型糖尿病患者,采用随机数字表法将其分为两组。对照组47例,采用胰岛素治疗;观察组47例,在此基础上联合应用达格列净治疗。比较两组患者不同时点的血糖水平、血糖波动指标、胰岛素用量及低血糖事件发生情况。结果治疗后,观察组患者各时点(早餐前后、午餐前后、晚餐前后、夜间1点)的血糖控制水平均优于对照组(P<0.05);治疗后,观察组患者的平均血糖(MBG)、血糖水平标准差(SDBG)、最大血糖波动幅度(LAGE)、餐后血糖波动幅度(PPGE)水平均低于对照组(P<0.05);观察组患者胰岛素用量低于对照组(P<0.05);两组患者均未出现严重低血糖事件。结论在胰岛素治疗基础上联用达格列净可提高血糖控制效果,降低血糖波动,减少胰岛素用量,应用效果良好。Objective To analyze the effect of dapagliflozin combined with insulin on patients with type 2 diabetes and its influence on blood glucose fluctuations.Method A total of 94 patients with type 2 diabetes in Zhengzhou People's Hospital from August 2018 to July 2020 were randomly divided into two groups by digit table.Forty-seven cases in the control group were treated with insulin;and 47 cases in the observation group were treated with dapagliflozin on this basis.The blood glucose levels,blood glucose fluctuation indicators,insulin dosage and occurrence of hypoglycemia events were compared between the two groups at different time points.Results After treatment,the blood glucose control level of the observation group was significantly better than that of the control group(P<0.05)at all time points(before and after breakfast,lunch,dinner,1 o'clock at night);after treatment,the levels of mean blood glucose(MBG),standard deviation of blood glucose level(SDBG),maximum blood glucose fluctuation range(LAGE),postprandial blood glucose fluctuation range(PPGE)were significantly lower than those of the control group(P<0.05);the insulin consumption of the observation group was significantly lower than that of the control group(P<0.05);there were no severe hypoglycemia events in the two groups.Conclusions Combining dapagliflozin on the basis of insulin therapy can improve the effect of blood glucose control,reduce blood glucose fluctuations,and reduce the amount of insulin,with good application effects.

关 键 词：糖尿病 胰岛素 达格列净 血糖 

分 类 号：R587.1[医药卫生—内分泌]