细胞药代动力学在蒽环类药物多药耐药及心脏毒性研究中的应用  

Application of cellular pharmacokinetics in the study of multidrug resistance and cardiotoxicity of anthracyclines

作　　者：康宇 曹培 董紫姗 张志清[1] KANG Yu;CAO Pei;DONG Zi-shan;ZHANG Zhi-qing(Department of Pharmacy,The Second Hospital of Hebei Medical University,Shijiazhuang 050000,Hebei Province,China;Department of Pharmacology,Hebei Medical University,Shijiazhuang 050017,Hebei Province,China)

机构地区：[1]河北医科大学第二医院药学部,河北石家庄050000 [2]河北医科大学药理学教研室,河北石家庄050017

出　　处：《中国临床药理学杂志》2021年第4期461-465,共5页The Chinese Journal of Clinical Pharmacology

基　　金：河北省重点研发计划课题资助项目(192777127D)。

摘　　要：蒽环类药物是经典有效的细胞毒性药物,多药耐药和药物不良反应是该类药物存在的棘手问题。细胞药代动力学研究可以明确蒽环类药物在胞内的动力学过程,针对目前存在的问题探寻解决方案。本文综述了细胞药代动力学在蒽环类药物多药耐药和心脏毒性研究中的应用及常用方法,旨在为之后的蒽环类药物的细胞药代动力学研究提供参考。Anthracyclines are classically effective cytotoxic drugs, but multidrug resistance and adverse reactions are the thorny problems of these drugs.Cellular pharmacokinetics can clarify the intracellular kinetics of anthracyclines and explore the solutions to the existing problems.This paper reviews the application and common methods of cellular pharmacokinetics in the study of multidrug resistance and cardiotoxicity of anthracyclines, in order to provide references for the further study of cellular pharmacokinetics of anthracyclines.

关 键 词：蒽环类 细胞药代动力学 多药耐药 心脏毒性 耐药逆转剂 

分 类 号：R979.1[医药卫生—药品]