生理药代动力学模型在药物基因组学中的应用  

Application of physiologically based pharmacokinetic models in pharmacogenomics

作　　者：姚莉 杨公炜[2] 李敏 丁宁[1] 相小强[1] YAO Li;YANG Gong-wei;LI Min;DING Ning;XIANG Xiao-qiang(School of Pharmacy,Fudan University,Shanghai 201203,China;Department of Laboratory,Jinan Infectious Disease Hospital,Shandong University,Jinan 250021,Shandong Province,China)

机构地区：[1]复旦大学药学院,上海201203 [2]山东大学附属济南市传染病医院检验科,山东济南250021

出　　处：《中国临床药理学杂志》2021年第4期487-489,共3页The Chinese Journal of Clinical Pharmacology

基　　金：国家自然科学基金资助项目(81473409);国家科技重大专项基金资助项目(2018ZX09711002-006-008)。

摘　　要：生理药代动力学模型作为药代动力学的新兴工具,可以有效用于表征各种情况下由基因组学多态性导致的体内药动学变化。本文介绍生理药代动力学模型在药物基因组学研究中的基本原理并讨论其适用性,从I相代谢酶、II相代谢酶和转运体的基因多态性角度总结了模型的应用情况,以期了解药物基因组学的新型研究手段,为促进药物临床应用和提高药物研发效率提供新思路和新方法。As a novel tool, the physiologically based pharmacokinetic(PBPK) model can be effectively used for characterizing pharmacokinetic changes in the body caused by genomics polymorphism in various conditions.This paper introduces the basic principle of PBPK model in pharmacogenomics research and discusses its applicability.It summarizes the application of PBPK model from the perspective of gene polymorphism of phase I metabolic enzymes, phase II metabolic enzymes and transporters, thus to provide methods for optimizing the clinical application of drugs and improving the efficiency of drug research and development.

关 键 词：生理药代动力学模型 药物基因组学 药物代谢酶 药物转运体 

分 类 号：R97[医药卫生—药品]