利拉鲁肽降压效应机制的研究进展  

Research progress of antihypertensive effect mechanism of liraglutide

作　　者：张学辉 李娟[1] ZHANG Xuehui;LI Juan(Endocrinology Department,Fuyang People's Hospital,Fuyang 236000,China)

机构地区：[1]阜阳市人民医院内分泌科,安徽阜阳236000

出　　处：《临床医学研究与实践》2021年第8期196-198,共3页Clinical Research and Practice

摘　　要：利拉鲁肽是常见胰高血糖素样肽-1(GLP-1)受体激动剂之一,除有良好的降糖效应外,在控制糖尿病患者血压、体重、血脂及减少蛋白尿、改善心功能等方面都有积极的影响,其治疗2型糖尿病有效性、患者耐受性良好。国内外多项临床和基础研究显示,利拉鲁肽具有一定的降压效应,其主要涉及的机制可能包括降低体重、增加尿钠排泄、减少游离脂肪酸(FFA)、改善内皮功能等方面。本文就利拉鲁肽的降压效应具体机制进行综述。Liraglutide is one of the common glucagon like peptide-1(GLP-1)receptor agonists.In addition to its good hypoglycemic effect,liraglutide has positive effects on controlling blood pressure,body weight,blood lipid,reducing proteinuria and improving cardiac function in patients with diabetes mellitus,which is effective and well tolerated in the treatment of type 2 diabetes mellitus.A number of clinical and basic studies at home and abroad have shown that liraglutide has a certain antihypertensive effect,and its main mechanisms may include reducing body weight,increasing urinary sodium excretion,reducing free fatty acids(FFA),improving endothelial function and so on.In this paper,the specific mechanism of antihypertensive effect of liraglutide is reviewed.

关 键 词：利拉鲁肽 血压 减重 尿钠 游离脂肪酸 内皮功能 

分 类 号：R587.1[医药卫生—内分泌]