黄连阿胶汤加减方治疗社区广泛性焦虑症42例效果观察  

Effect of modified Huanglian Ejiao Decoction on treatment of 42 cases of generalized anxiety disorder in community

作　　者：刁华琼 唐启盛 邵珺 田会玲[3] 丁海月 魏丹 李小黎 DIAO Hua-qiong;TANG Qi-sheng;SHAO Jun;TIAN Hui-ling;DING Hai-yue;WEI Dan;LI Xiao-li(Department of encephalopathy,the Third Affiliated Hospital of Beijing University of Chinese Medicine,Beijing 100029,China;Shanghai University of Chinese Medicine,Shanghai 201203;Beijing University of Chinese Mediciney,Beijing 100029)

机构地区：[1]北京中医药大学第三附属医院脑病科,北京100029 [2]上海中医药大学,上海201203 [3]北京中医药大学,北京100029

出　　处：《北京中医药》2020年第12期1225-1228,共4页Beijing Journal of Traditional Chinese Medicine

基　　金：国家中医药管理局2015年度中医药行业科研专项(201507001-12)。

摘　　要：目的观察黄连阿胶汤加减方治疗社区广泛性焦虑症(GAD)患者的临床效果。方法选取2015年1月—2016年5月就诊于北京中医药大学第三附属医院下属及周边的社区服务中心的心肾不交型GAD患者84例,采用随机数字表法分为观察组与对照组,各42例。观察组予黄连阿胶汤加减方治疗,对照组予劳拉西泮片治疗,疗程均为2周。比较2组治疗前后汉密尔顿焦虑量表(HAMA)评分和中医证候积分,依据HAMA减分率与疗效指数评价临床疗效,并于治疗结束3个月后随访。结果治疗1周后,2组HAMA评分疗效及中医证候疗效差异均无统计学意义(P>0.05);治疗2周后,2组HAMA评分疗效差异有统计学意义(P<0.05),中医证候疗效差异有统计学意义(P<0.01),不良反应量表评分差异有统计学意义(P<0.01);随访结果提示观察组的远期复发率较对照组低。结论黄连阿胶汤加减方能有效改善社区心肾不交型GAD患者的焦虑程度与中医证候,治疗相对安全。Objective To investigate the effect of modified Huanglian Ejiao(MHLEJ) Decoction on the treatment of generalized anxiety disorder(GAD)in community. Methods Eighty-four patients with heart-kidney disharmony type of GAD,who visited community health center under the Beijing University of Chinese Medicine and other nearby community health centers from January 2015 to May 2016,were selected and divided into experimental and control groups by using random number table method with forty-two cases each and respectively treated with MHLEJ Decoction and Lorazepam for two weeks. The Hamilton Anxiety Scale(HAMA) and TCM syndrome score were used to compare the results and evaluate the clinical efficacy,and the HAMA rate of score-reducing and efficacy index were used to assess the clinical efficacy before and after treatment of two groups. The follow-up at the third mouth was given after the treatment. Results The differences of scores of HAMA and TCM syndrome between the two groups had no statistical significance after one week of treatment(P>0.05);the difference of HAMA scores between the two groups had statistical significance after two weeks of treatment(P<0.05)and the efficacy of TCM syndrome was remarkably different(P<0.01),and the side effect score was remarkably different(P<0.01).The follow-up results showed that the long-term recurrence rate of the experimental group was lower than that of the control group. Conclusion The MHLEJ Decoction can improve anxiety and TCM symptoms of heart-kidney disharmony type of GAD in community with safety.

关 键 词：广泛性焦虑症 社区 黄连阿胶汤 心肾不交 

分 类 号：R277.7[医药卫生—中医学]