生物被膜与环二鸟苷酸信号系统  

Biofilm and c-di-GMP-mediated signaling pathway

作　　者：郑贤惠 汪钰鸿 张玥涛 张玉琴 陆聪 李水红[1] ZHENG Xianhui;WANG Yuhong;ZHANG Yuetao;ZHANG Yuqin;LU Cong;LI Shuihong(Institution of Pathogenic Biology,University of South China,Hengyang 421001,China)

机构地区：[1]南华大学病原生物学研究所,衡阳421001

出　　处：《生命的化学》2020年第12期2162-2169,共8页Chemistry of Life

基　　金：国家自然科学基金项目(81401512);湖南省大学生创新训练项目(S201910555140)。

摘　　要：环二鸟苷酸(c-di-GMP)是一种普遍存在于细菌胞内的核苷酸类小分子,是细菌特有的第二信使分子,参与调控细菌多种生理功能,包括生物被膜的形成。c-di-GMP信号系统包括信号分子的新陈代谢、信号分子的识别与接受、信号的放大与传递、基因表达与生理效应的产生。本文以c-di-GMP调控铜绿假单胞菌生物被膜形成为例,对该信号系统展开详细介绍,并进行讨论和总结。Cyclic diguanylate(c-di-GM P)is a small nucleotide molecule that is ubiquitous in bacterial cells and is a unique second m essenger o f bacteria.The c-di-GM P is also involved in regulating various physiological functions o f bacteria,including the formation o f biofilm,bacterial m otility and virulence expression.The c-di-GM P triggered signaling pathways in different ways including metabolism of signal molecule,recognition and binding o f signals,signal am plification and transm ission,which could further regulate gene expression and physiological effects.This work took the biofilm formation of Pseudomonas aeruginosa as an example,the c-di-GMP mediated bacterial signaling pathways and regulatory mechanisms were introduced in details.

关 键 词：生物被膜 环二鸟苷酸 信号转导 受体 调控机制 

分 类 号：Q935[生物学—微生物学]