新型冠状病毒肺炎患者入院时外周血血红蛋白水平及其与病程的相关性  

Level of hemoglobin in hospitalized patients with COVID-19 and its correlation with course of disease

作　　者：鲁成 庞家栋 刘永明[3] 王玉华[1] 庄少伟 LU Cheng;PANG Jiadong;LIU Yongming;WANG Yuhua;ZHUANG Shaowei(Shanghai Seventh People's Hospital,Shanghai 201203,China)

机构地区：[1]上海市第七人民医院,上海201203 [2]武汉雷神山医院 [3]曙光医院

出　　处：《山东医药》2021年第6期6-9,共4页Shandong Medical Journal

基　　金：国家自然科学基金面上项目(81973611);上海市卫生健康委员会科学研究项目(201940461);上海市青年科技英才扬帆计划(20YF1436800);上海市浦东新区临床高原学科(PWYgy2018-05);上海市第七人民医院人才培养计划(XX2018-03)。

摘　　要：目的观察新型冠状病毒肺炎(以下简称新冠肺炎)入院时患者外周血血红蛋白(Hb)水平,分析其与患者病程的相关性。方法 50例新冠肺炎患者,其中普通型39例、重型11例。入院时采集患者静脉血,检测血清Hb、红细胞(RBC)、白细胞(WBC)、血小板(PLT)、红细胞压积(HCT)、红细胞分布宽度(RDW)、淋巴细胞百分比(LYM%)、淋巴细胞绝对值(LYM#)及C反应蛋白(CRP)。分析血清Hb与患者住院时间、病程的相关性。结果入院时普通型患者血清RBC为(4.31±0.49)×10^(12)/L、WBC为(5.53±1.09)×10^(9)/L、PLT为(224.16±53.94)×10^(9)/L、Hb为(132.68±12.79)g/L,HCT为39.69%±4.08%、RDW-CV为13.05%±1.27%、LYM%为31.59±7.17、LYM#为1.76±0.53、CRP为1.40±1.45。入院时重症患者血清RBC为(3.49±0.59)×10^(12)/L、WBC为(5.10±1.62)×10^(9)/L、PLT为(199.56±37.85)×10^(9)/L、Hb为(107.33±15.47)g/L,HCT为32.97%±4.65%、RDW-CV为14.26%±1.47%、LYM%为22.83±10.19、LYM#为1.09±0.46、CRP为8.27±9.03。与普通型患者比较,重型新冠肺炎患者血清RBC、Hb、HCT、RDW-CV、LYM%、LYM#降低,血清CRP水平升高(P均<0.05)。根据Hb水平可将50例患者分为血清Hb低于正常者10例、血清Hb正常者40例,住院天数分别为(25.22±4.60)、(17.38±5.12)d,病程分别为(48.11±10.47)、(39.78±10.71)d。与血清Hb正常者比较,血清Hb低于正常者住院天数多,病程长(P均<0.05)。新冠肺炎患者住院天数与血清Hb水平呈负相关(r为-0.499;P<0.01)。结论与普通型患者比较,重型新冠肺炎患者入院时血清Hb降低,病程及住院时间更长。新型冠状病毒肺炎患者入院时外周血血红蛋白水平与病程无关。Objective2019(COVID-19)and to analyze the correlation between the level of Hb and the duration of disease.Methods COVID-19 patients were selected.There were 39 cases of common type and 11 cases of severe type.Hb,red blood cells(RBC),white blood cells(WBC),platelets(PLT),hematocrit(HCT),red blood cell distribution width(RDW),lymphocyte percentage(LYM%),lymphocyte absolute value(LYM#),and C-reactive protein(CRP)in the blood routine were detected.We analyzed the correlation between Hb and the length of hospital stay and course of disease.Results The level of RBC in serum of patients of common type was(4.31±0.49)×10^(12)/L,WBC was(5.53±1.09)×10^(9)/L,PLT was(224.16±53.94)×10^(9)/L,Hb was(132.68±12.79)g/L,HCT was 39.69%±4.08%,RDW-CV was 13.05%±1.27%,LYM%was 31.59±7.17,LYM#was 1.76±0.53,and CRP was 1.40±1.45.The level of RBC in serum of patients of severe type was(3.49±0.59)×10^(12)/L,WBC was(5.10±1.62)×10^(9)/L,PLT was(199.56±37.85)×10^(9)/L,Hb was(107.33±15.47)g/L,HCT was 32.97%±4.65%,RDW-CV was 14.26%±1.47%,LYM%was 22.83±10.19,LYM#was 1.09±0.46,and CRP was 8.27±9.03.Compared with patients of common type,patients of severe type had lower levels of RBC,Hb,HCT,RDW-CV,LYM%and LYM#,and higher level of CRP(all P<0.05).According to the level of Hb,50 patients were divided into the abnormal group of 10 cases and normal group of 40 cases,their length of stay was(25.22±4.60)and(17.38±5.12)d,respectively,and the course of disease was(48.11±10.47)and(39.78±10.71)d.Patients with lower hemoglobin levels had longer hospital stay and disease duration than normal patients(all P<0.05).Hospital stay of COVID-19 patients was negatively correlated with hemoglobin levels(r=0.499;P<0.01).Conclusions ease and hospital stay.The level of peripheral blood hemoglobin in patients with COVID-19 on admission had nothing to do with the course of disease.

关 键 词：血红蛋白 新型冠状病毒 新型冠状病毒肺炎 

分 类 号：R512.99[医药卫生—内科学]