人参皂苷参与调控神经系统功能的研究进展  

Research Progress of Ginsenosides on Regulating Nervous System Function

作　　者：万茜淋 吴新民[3] 刘淑莹 孙秀丽[1] Wan Xilin;Wu Xinmin;Liu Shuying;Sun Xiuli(Jilin Ginseng Academy,Changchun University of Chinese Medicine,Changchun 130117;Engineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi,Jilin Agricultural University,Changchun 130118;Department of Neurosurgery,the First Hospital of Jilin University,Changchun 130021;Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022)

机构地区：[1]长春中医药大学吉林省人参科学研究院,长春130117 [2]吉林农业大学食药用菌教育部工程研究中心,长春130118 [3]吉林大学第一医院神经肿瘤外科,长春130021 [4]中国科学院长春应用化学研究所,长春130022

出　　处：《中药药理与临床》2020年第6期230-235,共6页Pharmacology and Clinics of Chinese Materia Medica

基　　金：吉林省教育厅“十三五”科学技术项目(编号:JJKH20181274KJ);吉林省中医药管理局科技项目(编号:2018026)。

摘　　要：人参皂苷是人参中的主要活性成分,具有抗氧化、抗肿瘤、提高免疫功能和改善神经系统等作用。为进一步研究人参皂苷对神经系统调节方面的基础研究和临床应用,本研究以"人参皂苷、活性、神经系统"等为关键词,检索1990年~2020年Web of Science、PubMed、中国万方和中国知网等数据库,检索结果为中文文献265篇,外文文献50篇。通过对检索文献的查阅及整理,分类并总结了人参皂苷在神经系统调控方面的药理活性。检索发现人参皂苷对神经系统的调节作用广泛,包括神经保护作用、抗抑郁作用、改善认知功能和改善学习记忆功能等方面。本研究可为人参皂苷在神经系统疾病方面开拓药用范围,进一步明确药效机制,为人参皂苷在神经系统调节领域的研究打开思路。Ginsenoside is the main active ingredient in Ginseng,which has the anti-oxidation function,anti-tumor function,improving immune function and improving nervous system function.For further research on its regulating nervous system function in clinical application and basic research,in this article,"Ginsenoside,activity,nervous system"were taken as keywords to search in databases of Web of Science,PubMed,Wanfang,and CNKI during 1990-2020.265 Chinese literatures and 50 foreign literatures were obtained to summarize the pharmacological activities of Ginsenoside on nervous system.The results showed that Ginsenoside had the wide regulating nervous system effect,including nerve protective effect,antidepressant effect,improvement in cognitive function,improvement in learning and memory function.This study can widen the medicinal application range of Ginsenoside in nervous system diseases,further clarify its mechanism,and broaden the ideas of Ginsenoside in nervous system regulation.

关 键 词：人参皂苷 神经系统 退行性疾病 认知障碍 抑郁症 

分 类 号：R285[医药卫生—中药学]