新生儿溶血病与母体血型抗体IgG免疫球蛋白分型相关性分析  

Correlation analysis between neonatal hemolytic disease and Ig G immunoglobulin typing of maternal blood group antibody

作　　者：庞新丰 乔静 范贞 柳沛 PANG Xin-feng;QIAO Jing;FAN Zhen;LIU Pei(Department of Blood Transfusion,Jiaozuo Maternal and Child Health Care Hospital;Department of Pediatrics,Jiaozuo Maternal and Child Health Care Hospital)

机构地区：[1]焦作市妇幼保健院输血科,河南焦作454000 [2]焦作市妇幼保健院儿科一区,河南焦作454000

出　　处：《中国优生与遗传杂志》2020年第12期1489-1490,共2页Chinese Journal of Birth Health & Heredity

基　　金：河南省医学科技攻关计划联合共建项目,基金编号:LHGJ20191368。

摘　　要：目的通过回顾性分析新生儿溶血病阳性患儿实验室检测数据,得出新生儿溶血病与母体血型抗体IgG免疫球蛋白分型含量之间相关性。方法通过对231例新生儿溶血病患儿阳性标本统计,分析母体血型抗体效价水平,以及母体血型抗体IgG免疫球蛋白分型在不同血型系统新生儿溶血病中的含量。结果新生儿溶血病阳性46例中以母婴ABO血型系统不合常见约占82.6%,abo系统溶血以母亲O型婴儿B型不合为最常见占abo系统的55.3%;abo系统38例阳性患者高于医学参考区间的34例,4例低于医学参考区间。非abo系统8例阳性患者高于医学参考区间的6例,2例低于医学参考区间。高于医学参考区间组新生儿溶血病阳性的患者,母体IgG1分型检测数值平均值均高于正常值,低于医学参考区间组非abo系统新生儿溶血病阳性患者,母体IgG3分型检测数值平均值均高于正常值。结论新生儿溶血病阳性患儿母体血型效价大多超过医学参考区间,新生儿溶血病与IgG1含量增高相关,存在低效价发生新生儿溶血病的病例与IgG3增高相关。Objective:To find the correlation between neonatal hemolysis and maternal antibody IgG immunoglobulin typing by retrospective analysis of laboratory test data of children with positive neonatal hemolysis.Methods:The titer level of maternal blood group antibody and the content of IgG immunoglobulin typing of maternal blood group antibody in neonate hemolysis of different blood group systems were analyzed by the statistic of 231 positive samples of neonate hemolysis.Results:Among the 46 cases with positive hemolysis of newborn,the ABO blood group system incompatibility was the most common,accounting for 82.6%,and the ABO blood group system incompatibility was the most common,accounting for 55.3%.Thirty-four of the 38 abo positive patients were above the medical reference interval,and four were below.Six of the eight non-abo positive patients were above the medical reference interval,and two were below.The mean values of maternal IgG1 typing were higher than normal in the patients with positive hemolysis in the medical reference interval group.The mean values of maternal IgG3 typing were higher than the normal values in the non-abo system neonate hemolysis positive patients lower than the medical reference interval.Conclusion:The maternal blood group titer of newborn children with positive hemolytic disease exceeds the medical reference range,neonatal hemolytic disease is associated with increased IgG1 content,and cases of neonatal hemolytic disease with low efficiency are associated with increased IgG3.

关 键 词：HDN血型抗体 免疫球蛋白分型 

分 类 号：R722.18[医药卫生—儿科]