冻融胚胎移植日血清E2、P水平及P/E2对妊娠结局的预测价值探讨  

Explore of the predictive value of serum E,P levels and P/E on the day of freeze-thaw embryo transfer on pregnancy outcomes

作　　者：刘宁[1] LIU Ning(Reproductive Center,Handan Central Hospital,Handan 056000,Hebei)

机构地区：[1]邯郸市中心医院生殖中心,河北邯郸056000

出　　处：《中国优生与遗传杂志》2020年第12期1517-1519,1526,共4页Chinese Journal of Birth Health & Heredity

基　　金：不同因素对冻融胚胎移植周期妊娠率的影响,项目编号:19422083015ZC。

摘　　要：目的探讨冻融胚胎移植日血清雌二醇(E2)、孕酮(P)水平及P/E2对妊娠结局的预测价值。方法回顾性分析2018年5月~2020年5月医院收治的126例行冻融胚胎移植的不孕症患者的资料,根据妊娠结果,将妊娠成功患者记为A组,妊娠失败患者记为B组。统计妊娠成功率,对比2组患者冻融胚胎移植日血清E2、P水平及P/E2,采用受试者工作特征曲线(ROC)分析冻融胚胎移植日血清E2、P水平及P/E2预测妊娠成功的效能。结果所有患者中妊娠成功65例,妊娠成功率为51.59%;2组基本资料差异无统计学意义(P>0.05),A组患者冻融胚胎移植日血清E2水平及P/E2高于B组患者(P<0.05),P水平低于B组患者(P<0.05);冻融胚胎移植日血清E2、P水平及P/E2预测妊娠成功的ROC分析显示,血清E2、P水平及P/E2的最佳截断点分别为161.68 pg/mL,43.16 ng/mL,287.81,灵敏度分别为75.38%,87.69%,和78.46%,特异度分别为78.69%,70.49%和72.13%,三者联合的灵敏度、特异度、曲线下面积(AUC)分别为75.38%,98.36%和0.905,且特异度和AUC均最高(P<0.05)。结论冻融胚胎移植妊娠成功率低,妊娠成功患者冻融胚胎移植日血清E2水平及P/E2高于妊娠失败患者,P水平低于妊娠失败患者,冻融胚胎移植日血清E2、P水平及P/E2联合预测妊娠成功的效能较单个指标更佳。Objective:To explore the predictive value of serum estradiol(E2),progesterone(P)levels and P/E2 on the date of freeze-thaw embryo transfer on pregnancy outcomes.Methods:The data of 126 infertility patients who underwent freeze-thaw embryo transfer in the hospital from May 2018 to May 2020 were retrospectively analyzed,according to the pregnancy results,patients with successful pregnancy were recorded as group A,and patients with failed pregnancy were recorded as group B.The pregnancy success rate was counted,serum E2,P levels and P/E2 on the day of frozen-thawed embryo transfer between the two groups were compared,the receiver operating characteristic curve(ROC)was used to analyze the efficacy of serum E2,P levels and P/E2 in predicting pregnancy success on the day of freeze-thaw embryo transfer.Results:A total of 65 patients had successful pregnancy among all patients,and the pregnancy success rate was 51.59%.There were no statistically significant difference in basic data between the two groups(P>0.05),and the serum E2 level and P/E2 of the patients in group A were higher than those in group B(P<0.05)on the day of frozen-thawed embryo transfer,and the P level was lower than those in group B(P<0.05).ROC analysis of serum E2,P levels and P/E2 on the day of freeze-thaw embryo transfer predicting pregnancy success showed that the best cut-off points of serum E2,P levels and P/E2 were 161.68 pg/mL,43.16 ng/mL,and 287.81,respectively,the sensitivity were 75.38%,87.69%,and 78.46%,and the specificity were 78.69%,70.49%,and 72.13%,respectively,the sensitivity,specificity,and area under the curve(AUC)of the three combinations were 75.38%,98.36%and 0.905,respectively,and the specificity and AUC were the highest(P<0.05).Conclusion:The pregnancy success rate of freeze-thaw embryo transfer is low,the serum E2 level and P/E2 of the frozen-thawed embryo transfer day of the successful pregnancy patients are higher than those of the failed pregnancy patients,and the P level is lower than that of the failed pregnancy patients,The

关 键 词：冻融胚胎移植 雌二醇 孕酮 P/E2比值 妊娠结局 

分 类 号：R714.8[医药卫生—妇产科学]