千金苇茎汤辅助胸腺肽α1治疗ICU重症肺炎合并G-菌感染疗效观察及对血浆ANP、NT-proBNP的影响  

Observation of Qianjin Weijing Tang Assisting Thymosinα1 for ICU Patients with Severe Pneumonia Complicated with G-Bacteria Infections and Its Effect on ANP and NT-proBNP in Plasma

作　　者：张楚明[1] 何宗广[1] 郑诚[1] 徐盼盼 ZHANG Chuming;HE Zongguang;ZHENG Cheng;XU Panpan

机构地区：[1]台州市立医院ICU,浙江台州318000

出　　处：《新中医》2021年第4期61-64,共4页New Chinese Medicine

摘　　要：目的:观察千金苇茎汤加减辅助胸腺肽α1治疗ICU重症肺炎合并G-菌感染的临床疗效,分析对血浆心钠肽(ANP)与B型氨基端利钠肽原(NT-proBNP)的影响。方法:将ICU重症肺炎合并G-菌感染患者100例,通过随机分组的方式分为观察组与对照组,各50例。对照组采用胸腺肽α1进行治疗,观察组在此基础上联用千金苇茎汤加减进行治疗,对比2组临床疗效、炎性状态及心损伤相关指标间的差异。结果:观察组总有效率为92.0%,对照组总有效率为72.0%,观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前,2组C-反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平均无明显差异(P>0.05);治疗后,2组各炎症指标均有所降低,观察组各指标的下降程度大于对照组,差异有统计学意义(P<0.05)。观察组ANP与NT-proBNP水平均低于对照组,2组比较,差异有统计学意义(P<0.05)。结论:千金苇茎汤加减辅助胸腺肽α1治疗ICU重症肺炎合并G-菌感染的临床疗效显著,可有效抑制炎症反应,改善免疫功能。Objective:To observe the clinical effect of modified Qianjin Weijing tang assisting thymosinα1 for ICU patients with severe pneumonia complicated with G-bacteria infections,and to analyze its effect on atrial natriuretic peptide(ANP)and N-terminal pro-B-type natriuretic peptide(NT-proBNP)in plasma.Methods:A total of 100 cases of ICU patients with severe pneumonia complicated with G-bacteria infections were randomly divided into the observation group and the control group,50 cases in each group.The control group was treated with thymosinα1,and the observation group was additionally treated with modified Qianjin Weijing tang based on the treatment of the control group.The differences in clinical effect,inflammatory state and related indexes of heart injuries between the two groups were compared.Results:The total effective rate was 92.0%in the observation group,higher than that of 72.0%in the control group,the difference being significant(P<0.05).Before treatment,there was no significant difference being found in the comparison of the levels of C-reactive protein(CRP),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)between the two groups(P>0.05);after treatment,the inflammatory factors in the two groups were decreased,and the decrease in the observation group was larger than that in the control group,the difference being significant(P<0.05).The levels of ANP and NT-proBNP in the observation group were lower than those in the control group,the difference being significant(P<0.05).Conclusion:Modified Qianjin Weijing tang assisting thymosinα1 has significant clinical effect in treating ICU patients with severe pneumonia complicated with G-bacteria infections,which can effectively inhibit inflammatory responses and improve immune function.

关 键 词：重症肺炎 G-菌感染 千金苇茎汤 心钠肽 B型氨基端利钠肽原 

分 类 号：R563.1[医药卫生—呼吸系统]