血液接触生物材料的血液相容性评价研究进展  被引量:5

Advances in the Evaluation of Blood Compatibility of Blood-contact Biomaterials

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作  者:秦政 杨钦博 苏白海[1] QIN Zheng;YANG Qin-bo;SU Bai-hai(Department of Nephrology,West China Hospital,Sichuan University,Chengdu 610041,China)

机构地区:[1]四川大学华西医院肾脏内科,成都610041

出  处:《高分子通报》2021年第2期1-8,共8页Polymer Bulletin

基  金:国家重点研发计划(2016YFC1103003)。

摘  要:生物材料的血液相容性是决定该材料能否在临床成功应用的重要标准之一。当材料与血液接触后,会引起溶血、凝血和免疫等一系列反应,机制复杂且受多种因素影响。因此,在材料临床应用前需根据ISO 10993-4进行生物相容性评价,血液相容性评价是其中重要部分,但目前尚未形成统一的评价标准与评价体系。本文总结了近年对血液相容性评价的主要方法,为今后生物材料血液相容性评价体系的建立提供参考。The blood compatibility of biomaterials is one of the important criteria for the successful clinical application. When materials come into contact with blood, they will cause a series of complex reactions, such as hemolysis, coagulation and immunity, and the mechanism is complex and affected by a variety of factors. Therefore, biocompatibility evaluation of materials should be conducted according to ISO 10993-4 before their clinical application. Blood compatibility evaluation is an important part of it, but there is no unified evaluation standard and index so far. In this paper, the main methods of blood compatibility evaluation in recent years were summarized to provide reference for the establishment of biomaterial blood compatibility evaluation system in the future.

关 键 词:生物材料 血液相容性 评价 

分 类 号:R318.08[医药卫生—生物医学工程]

 

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