吴良村辨治消化系统肿瘤用药规律分析  

An Analysis of the Administration Rule of WU Liangcun in Treating Tumors of Digestive System Based on Syndrome Differentiation

作　　者：冯妤茜 金慧敏 郭凯波 阮善明[2] FENG Yuqian;JIN Huimin;GUO Kaibo;RUAN Shanming

机构地区：[1]浙江中医药大学第一临床医学院,浙江杭州310053 [2]浙江中医药大学附属第一医院,浙江杭州310006

出　　处：《新中医》2021年第2期82-86,共5页New Chinese Medicine

基　　金：浙江省卫生高层次创新人才培养工程项目(2015-43);中华中医药学会青年人才托举工程项目(QNRC2-C08);浙江省高等学校中青年学科带头人培养对象项目(2017-248)。

摘　　要：目的:总结分析吴良村辨治消化系统肿瘤的用药规律。方法:收集2017年1月1日—2019年3月31日吴良村教授门诊消化系统肿瘤患者79例583诊次。将患者临床信息转化为方剂基础数据库,对药物累计频数、药物类别、药物性味采用描述性分析,对频数最高的50种药物进行系统聚类分析以及关联规则分析。结果:79例患者583诊次共用药199种,累计用药频次10 753次,其中用药频次最多者为佛手,其后依次为白芍、茯苓、山药、甘草等。药物类别使用最多的为补虚药,其后分别为清热药、利水渗湿药以及理气药等。药性使用频次最多的为平性,药味使用频次最多的为甘味。聚类分析将药物分为16类,涉及方剂四君子汤等。二药关联规则涉及太子参与山药、茯苓、白术等药对,三药关联规则涉及补虚药+利水渗湿药、补虚药+解表药、清热药+补虚药、消食药+补虚药+利水渗湿药、理气药+补虚药等配伍。结论:吴良村辨治消化系统肿瘤以健脾益气为主,随证辅以利水渗湿、解毒抗癌、消食和中之法,临证用药善于甘、苦、辛、平配伍。Objective:To summarize and analyze the administration rule of Prof. WU Liangcun in treating tumors of digestive system based on syndrome differentiation. Methods:From January 1,2017 to March 31,2019,79 patients with tumors of digestive system in Prof. Wu’s outpatient clinic were collected, with 583 consultations in total. The clinical information of the patients was converted into the basic database of prescription. Descriptive analysis was conducted on the cumulative frequency,the category,the nature and flavor of Chinese herbs,and systematic cluster analysis and association rule analysis were conducted on the 50 herbs most frequently-used. Results:A total of 79 patients were treated with 199 kinds of herbs in all 583 consultations,and the cumulative frequency of used herbs was 10,753,among which the most frequently-used herbs were Fructus Citri Sarcodactylis, followed by Radix Paeoniae Alba, Poria, Rhizoma Dioscoreae,Radix et Rhizoma Glycyrrhizae and others. The most commonly-used herbal categories belonged to deficiencysupplementing medicine,followed by heat-clearing medicine,urination-promoting and dampness-percolating medicine,qi-regulating medicine and others. The nature of the most frequently-used herbs was neutral,and the flavor of the most frequently-used herbs was sweet. By cluster analysis, the Chinese herbs used were divided into sixteen categories,involving prescriptions like Sijunzi tang, etc. By the rule of two-medicine association, there were herbal combinations including Radix Pseudostellariae and Rhizoma Dioscoreae,Poria,Rhizoma Atractylodis Macrocephalae,respectively. By the rule of three-medicine association, there were medicinal combinations including deficiency-supplementing medicine plus urination-promoting and dampness-percolating medicine, deficiency-supplementing medicine and exterior-releasing medicine,heat-clearing medicine and deficiency-supplementing medicine,digestion-promoting medicine and deficiencysupplementing medicine plus urination-promoting and dampness-percolating medicine

关 键 词：消化系统肿瘤 吴良村 名中医经验 数据挖掘 

分 类 号：R273[医药卫生—中西医结合]