五禽戏联合推拿对原发性痛经患者中医证候及血清TNF-α、CD4^(+)、OT、β-EP表达的影响  

Effect of Five Mimic-Animal Exercise Combined with Tuina on Chinese Medicine Syndromes and Expressions of TNF-α,CD4^(+),OT and β-EP in Serum in Patients with Primary Dysmenorrhea

作　　者：朱秀英 李永平[2] 孙小月 王修银 洒玉萍[2] 韩常安 ZHU Xiuying;LI Yongping;SUN Xiaoyue;WANG Xiuyin;SA Yuping;HAN Changan

机构地区：[1]西宁市中医院,青海西宁810000 [2]青海大学医学院,青海西宁810016

出　　处：《新中医》2021年第2期201-205,共5页New Chinese Medicine

基　　金：青海省西宁市科技项目(2017-K-17)。

摘　　要：目的:观察五禽戏联合推拿治疗原发性痛经(PD)的临床疗效及对患者血清肿瘤坏死因子-α(TNF-α)、CD4^(+)、催产素(OT)及β-内啡肽(β-EP)水平的影响。方法:选取80例PD女大学生,按随机数字表法分为对照组、五禽戏组、推拿组及五禽戏^(+)推拿组,对照组给予田七痛经胶囊治疗,其余3组分别给予五禽戏、推拿及五禽戏+推拿治疗,治疗时间均为3个月经周期。采用中医证候积分评价临床疗效,通过血清TNF-α、CD4^(+)、OT、β-EP表达的变化探讨五禽戏联合推拿治疗PD的作用机制。结果:与治疗前比较,4组中医证候积分治疗1个疗程、2个疗程、3个疗程后均降低(P<0.05),且随着疗程增加逐渐降低。停止治疗3个月后,4组中医证候积分均较治疗3个疗程时上升(P<0.05);五禽戏+推拿组中医证候积分低于五禽戏组和推拿组,差异均有统计学意义(P<0.05)。治疗后,4组血清TNF-α、OT水平均较治疗前降低(P<0.05),血清CD4^(+)、β-EP水平均较治疗前升高(P<0.05)。4组治疗后CD4^(+)、OT水平比较,差异均有统计学意义(P<0.05),而TNF-α、β-EP水平比较,差异均无统计学意义(P>0.05)。治疗后,五禽戏+推拿组OT水平均低于对照组、五禽戏组及推拿组(P<0.05),CD4^(+)水平高于对照组(P<0.05)。经秩和检验,4组临床疗效比较,差异无统计学意义(P>0.05)。结论:五禽戏联合推拿治疗PD有较好的近期及远期疗效,其作用机制可能与调节患者的血清TNF-α、CD4^(+)、OT、β-EP水平有关。Objective:To observe the clinical effect of five mimic-animal exercise combined with tuina for primary dysmenorrhea(PD) and its effect on the levels of tumor necrosis factor-α(TNF-α),CD4^(+),oxytocin(OT) and β-endorphin(β-EP) in serum.Methods:A total of 80 cases of female college students with PD were divided into the control group,the five mimic-animal exercise group, the tuina group and the five mimic-animal exercise combined with tuina group. The control group was treated with Tianqi Tongjing capsules, and the other three groups was respectively given five mimicanimal exercise,tuina,five mimic-animal exercise and tuina. All groups were treated for three menstrual cycles. The clinical effect was evaluated by Chinese medicine syndrome scores. The mechanism was discussed by the changes of expressions of TNF-α,CD4^(+),OT and β-EP in serum.Results:Compared with those before treatment,the Chinese medicine syndrome scores in the four groups were decreased after one,two and three courses of treatment(P<0.05),and gradually decreased with the increase of the course. Three months after treatment,the Chinese medicine syndrome scores in the four groups were increased when compared with those after three-course treatment(P<0.05);the score in the five mimic-animal exercise and tuina group was lower than those in the five mimic-animal exercise group combined with the tuina group,differences being significant(P<0.05). After treatment, the levels of TNF-α and OT in serum in the four groups were decreased when compared with those before treatment(P<0.05),and the levels of CD4^(+)and β-EP in serum were increased(P<0.05). After treatment, the comparisons of levels of CD4^(+)and OT among the four groups showed significance in differences(P<0.05),and there was no significant difference being found in the comparison of TNF-α and β-EP among the four groups(P>0.05). After treatment,the OT level in the five mimic-animal exercise combined with tuina group was lower than those in the control group,the five mimic-animal exercise

关 键 词：原发性痛经 五禽戏 推拿 中医证候 肿瘤坏死因子-α CD4^(+) 催产素 β-内啡肽 

分 类 号：R271.11+3[医药卫生—中医妇科学]