跟踪式干预对新生儿缺血缺氧性脑病生长及智能发育的影响  

Effect of following-up intervention on the growth and intelligent development of neonatal hypoxic-ischemic encephalopathy

作　　者：周红 吴娜娜 符婕 李宏 王颖 ZHOU Hong;WU Na-na;FU Jie;LI Hong;WANG Ying(Department of Neonatology,Chengdu Women’s and Children’s Central Hospital,Chengdu 610091;Children’s Health Guidance Center of Chengdu Women’s and Children’s Central Hospital,Chengdu 610091)

机构地区：[1]成都市妇女儿童中心医院新生儿科,成都610091 [2]成都市妇女儿童中心医院儿童保健指导中心,成都610091

出　　处：《中国优生与遗传杂志》2020年第11期1373-1376,共4页Chinese Journal of Birth Health & Heredity

基　　金：国家自然科学基金;青年基金项目,立项编号:81401247。

摘　　要：目的分析跟踪式干预对新生儿缺血缺氧性脑病(HIE)生长及智能发育的影响。方法将80例HIE新生儿按照纳入研究的顺序以自然数编号,并以随机数表分为常规组和研究组,2组院内干预措施相同,常规组出院后仅定时复诊,研究组出院后定时复诊的同时接受跟踪式干预。对比2组3月龄、6月龄、1周岁时身高、体质量;对比2组3月龄、6月龄、1周岁时智能发育指数(MDI)和发育商数(DQ);1周岁时评价并对比2组干预效果。结果身高、体质量、MDI和DQ经重复测量方差分析组间、时间、交互作用比较差异均有统计学意义(P<0.05),2组6月龄、1周岁身高、体质量、MDI和DQ均高于3月龄,2组1周岁身高、体质量、MDI和DQ均高于6个月,且研究组3月龄、6月龄、1周岁身高、体质量、MDI和DQ均高于常规组,本组内每2个时刻相比、各时刻2组间相比差异均有高度统计学意义(P<0.01);2组干预效果评价等级分布经秩和检验差异有统计学意义(P<0.05),且研究组优良率高于常规组,经χ2检验差异有统计学意义(P<0.05)。结论对新生儿HIE实施跟踪式干预可促进生长和智能发育,效果理想。Objective:To analyze the effect of follow-up intervention on the growth and intelligent development of neonatal hypoxic ischemic encephalopathy(HIE).Methods:80 neonates with HIE were randomly divided into two groups according to the order of inclusion in the study:the routine group and the study group,and the routine group only had regular follow-up after discharge,while the study group received following-up intervention at the same time of regular follow-up after discharge.The height and body mass of the two groups were compared at the age of 3 months,6 months and 1 year.The intelligence development index(MDI)and development quotient(DQ)at the age of 3 months,6 months and 1 year were compared between the two groups.At one year’s old,the intervention effect of the two groups was evaluated and compared.Results:There were significant differences in height,body mass,MDI and DQ between the two groups and in moments and interaction by repeated measurement analysis of variance(P<0.05).The height,body mass,MDI and DQ of the two groups at 6 months old and 1 year’s old were higher than those of the 3 months old,and the height,body mass,MDI and DQ of the two groups at 1 year’s old were higher than those at 6 months old,of which the study group at 3 months,6 months and 1 year’s old were higher than those of the control group,and there were highly significant differences between each two moments in the same group and between the two groups at every moments(P<0.01).There was a significant difference between the two groups in the intervention effect evaluation grade distribution by Rank sum text(P<0.05),and the excellent rate of the study group was higher than that of the routine group,with a statistically significant difference tested by χ^(2)(P<0.05).Conclusion:The following-up intervention can promote the growth and intelligent development of HIE,and the effect is ideal.

关 键 词：跟踪式干预 新生儿 缺血缺氧性脑病 生长 智能发育 

分 类 号：R722.1[医药卫生—儿科]