Ⅳ型心肾综合征发病机制研究新进展  

New progress in the pathogenesis of type Ⅳcardiorenal syndrome

作　　者：姚超逸 张义德[2] YAO Chaoyi;ZHANG Yide(School of Medicine,Nantong University,Nantong 226001,China)

机构地区：[1]南通大学医学院,江苏南通226001 [2]南通大学附属医院,江苏南通226001

出　　处：《实用医学杂志》2021年第4期542-546,共5页The Journal of Practical Medicine

基　　金：国家自然科学基金面上项目(编号:81670699)。

摘　　要：Ⅳ型心肾综合征对于慢性肾脏病患者的死亡率和预后具有重要的影响。但目前对于Ⅳ型心肾综合征发病机制的了解还不全面,治疗手段还不能有效控制Ⅳ型心肾综合征对慢性肾脏病患者生命的威胁。因此还需要对Ⅳ型心肾综合征的发病机制进一步深入研究,以开发出新的有效治疗手段。本文将近年重点关注的Ⅳ型心肾综合征发病机制的新进展做一综述,以期为药物研发提供依据,并指导临床诊断和治疗。TypeⅣcardiorenal syndrome plays an important role in the mortality and prognosis of patients with chronic kidney disease(CKD).At present,the understanding of the pathogenesis of typeⅣcardiorenal syndrome is not comprehensive,and current treatment methods cannot effectively control the life threat of typeⅣcardiorenal syndrome to CKD patients.Therefore,it is necessary to further explore the pathogenesis of typeⅣcardiorenal syndrome and develop new effective therapy methods.This article attempts to review the recent progress in the pathogenesis of typeⅣcardiorenal syndrome,which might provide the basis for medicine design and guide clinical diagnosis and treatment.

关 键 词：心肾综合征 发病机制 骨盐代谢 炎症 血管紧张素系统 

分 类 号：R541.9[医药卫生—心血管疾病]