BINOL轴手性胍催化合成3,4-二氢嘧啶硫酮  

Synthesis of 3,4-dihydropyrimidinthione catalyzed by BINOL axial chiral guanidine

作　　者：秦婷 安雪婕 莫丽 陈治明 QIN Ting;AN Xuejie;MO Li;CHEN Zhiming(Key Laboratory of Functional Materials Chemistry of Guizhou Province,School of Chemistry and Materials Science,Guizhou Normal University,Guiyang,Guizhou 550025,China)

机构地区：[1]贵州师范大学化学与材料科学学院贵州省功能材料化学重点实验室,贵州贵阳550025

出　　处：《贵州师范大学学报（自然科学版）》2021年第2期31-35,共5页Journal of Guizhou Normal University：Natural Sciences

基　　金：国家自然科学基金(No.21362006)。

摘　　要：以具有C 2轴手性结构的联萘酚酸骨架为原料,采用DCC-HOBt缩合法在联萘骨架上引入胍基,成功地合成了4个新型多氢键BINOL轴手性胍类催化剂,并将其成功应用于催化三组分不对称Biginelli反应。实验结果表明:在50℃条件下反应24 h,以甲醇为溶剂,1b作催化剂,取得了较好的收率(86%)。Four novel BINOL axial chiral guanidine amides with multiple hydrogen bonds were synthesized by DCC-HOBt condensation from the enantiomeric structure of binapholic acid,and applied to three-component asymmetric Biginelli reaction.The results showed that the yield(86%)of the reaction were good when methanol was used as solvent and 1b as catalyst.

关 键 词：胍催化剂 3 4-二氢嘧啶硫酮 BIGINELLI反应 

分 类 号：O622.7[理学—有机化学]