SIRT1改善糖尿病血管内皮功能的机制研究进展  

Research progress in the mechanism of SIRT1 improving diabetic vascular endothelial function

作　　者：雷永芳 聂雪坤 林敏华[2] 汪余嘉 陈子春 LEI Yongfang;NIE Xuekun;LIN Minhua;WANG Yujia;CHEN Zichun(School of Pharmacy,Fujian University of Traditional Chinese Medicine,Fuzhou 350122,China;Department of Clinical Pharmacy,Ningde Municipal Hospital,Ningde 352100,China)

机构地区：[1]福建中医药大学药学院,福建福州350122 [2]宁德市医院临床药学室,福建宁德352100

出　　处：《药学研究》2021年第2期119-122,共4页Journal of Pharmaceutical Research

基　　金：福建省卫生计生委医学创新课题资助计划项目(No.2017-CX-50);福建省科技厅自然科学基金面上项目(No.2018J01224)。

摘　　要：血管内皮功能障碍是糖尿病血管并发症发生的始动因素和主要病理生理学基础,是糖尿病血管病变的早期标志。临床治疗糖尿病的最终目的就是预防糖尿病血管病变,故改善血管内皮功能障碍是治疗糖尿病重要标靶。大量研究表明SIRT1与高糖所致内皮损伤密切相关,可通过抵抗炎症、氧化、衰老等改善血管内皮细胞功能。文章将对SIRT1改善血管内皮功能的机制研究作简要概述。Vascular endothelial dysfunction is the initiating factor and main pathophysiological basis of diabetic vascular complications,and it is an early sign of diabetic vascular disease.The ultimate goal of clinical treatment of diabetes is to prevent diabetic vascular disease,so improving vascular endothelial dysfunction is an important target for the treatment of diabetes.A large number of studies have shown that SIRT1 is closely related to high glucose induced endothelial injury and can improve the function of vascular endothelial cells by resisting inflammation,oxidation,and senility.This article will briefly summarized the mechanism of SIRT1 improving vascular endothelial function.

关 键 词：糖尿病 内皮功能障碍 SIRT1 

分 类 号：R587.1[医药卫生—内分泌]