人芽囊原虫感染动物模型构建研究进展  

Progress of researches on animal models of Blastocystis hominis infections

作　　者：冯霞 张富强 徐福阳 梅雪芳 张振超 李祥瑞 王帅[1,2] FENG Xia;ZHANG Fu-Qiang;XU Fu-Yang;MEI Xue-Fang;ZHANG Zhen-Chao;LI Xiang-Rui;WANG Shuai(School of Basic Medical Sciences,Xinxiang Medical University,Xinxiang 453003,China;Xinxiang Key Laboratory of Pathogenic Biology,Xinxiang Medical University,China;College of Veterinary Medicine,Nanjing Agricultural University,China)

机构地区：[1]新乡医学院基础医学院,新乡453003 [2]新乡医学院新乡市病原生物学重点实验室 [3]南京农业大学动物医学院

出　　处：《中国血吸虫病防治杂志》2021年第1期102-106,共5页Chinese Journal of Schistosomiasis Control

基　　金：新乡医学院大学生科研创新课题项目(xyxskyz201907);国家自然科学基金项目(81702025);河南省科技攻关计划项目(182102310220)。

摘　　要：人芽囊原虫是一种常见的寄生于人和动物肠道内的寄生原虫,其致病性尚有争议。构建动物模型对于研究人芽囊原虫致病性、致病机制以及药物筛选等具有重要意义。实验动物、感染方式和虫体选择以及宿主免疫状态是影响人芽囊原虫感染动物模型构建的重要因素。本文综述了近年来人芽囊原虫感染动物模型的相关研究进展,阐述了构建人芽囊原虫感染动物模型的影响因素及其应用,旨在为动物感染模型选择提供借鉴。Blastocystis hominis is a common parasitic protozoa in human and animal intestines;however,its pathogenicity remains controversial.Construction of animal models is of great significance to investigate the pathogenicity,pathogenic mechanisms and drug screening of B.hominis.Experimental animals,mode of infections,parasite strains and host immune status are important factors affecting the successful modeling of B.hominis infections in animals.Hereby,we review the progress of researches on animal models of B.hominis infections,and summarize the influencing factors and application of animal models of B.hominis infections,in order to provides insights into the selection of animals models of B.hominis infections.

关 键 词：人芽囊原虫 动物模型 感染途径 感染剂量 影响因素 

分 类 号：R382.9[医药卫生—医学寄生虫学]