重庆市2015—2019年免费抗结核固定剂量复合制剂使用核查分析  

Analysis on the use of free anti-tuberculosis fixed-dose combination in Chongqing,2015-2019

作　　者：李丹 吴成果 陈健 张娅 汪清雅 LI Dan;WU Cheng-guo;CHEN Jian;ZHANG Ya;WANG Qing-ya(Chongqing Tuberculosis Control Institute,Chongqing 400050,China)

机构地区：[1]重庆市结核病防治所,重庆400050

出　　处：《中国热带医学》2021年第3期229-233,共5页China Tropical Medicine

基　　金：重庆市科卫联合医学科研项目(No.2021MSXM184)。

摘　　要：目的通过分析2015—2019年重庆市免费抗结核固定剂量复合制剂(FDC)使用核查差异度,间接评价新型结核病防治服务模式转型前后抗结核药品使用的合理性,为药品的需求测算、采购、分发、使用和监管督导提供参考依据。方法利用中国疾病预防控制信息系统获取2015—2019年登记的结核病患者例数和抗结核药品发放量季度报表等数据,分别计算出各区县FDC-HRZE和FDC-HR的年度理论消耗量和实际消耗量,再利用药品使用核查差异度的计算公式,核对全市及四个区域FDC使用核查差异度。结果 2015—2019年重庆市FDC-HRZE和FDC-HR的使用核查平均差异度分别为-43.70%和-31.34%,主城区为-52.91%和-45.38%,都市圈为-39.01%和-24.51%,渝东北三峡库区城镇群为-42.00%和-30.75%,渝东南武陵山区城镇群为-47.73%和-29.25%,均超出了设定的±25%范围。在新型结核病防治服务模式完成转型后,全市2018年FDC-HRZE和FDC-HR的使用核查平均差异度分别为-22.19%和-21.36%,2019年分别为-21.65%和-16.43%,均在设定的±25%范围之内。其中,主城区在2018年的FDC-HRZE与FDC-HR使用核查差异度分别为-29.90%、-36.36%,2019年为-29.69%、-11.67%;都市圈2018年为-20.34%、-20.54%,2019年为-8.73%、-0.19%;渝东北三峡库区城镇群2018年为-18.51%、-17.07%,2019年为-19.72%、-21.36%;渝东南武陵山区城镇群2018年为-26.54%、-11.47%,2019年为-54.10%、-56.45%。结论近年来我市免费抗结核药品管理工作已经取得一定成效,完成转型后免费抗结核药品使用较为合理,但存在较大的地区差异,建议每半年或一年开展一次药品使用核查,对于差异度较大的地区建议每季度开展一次,并结合现场督导,加强患者管理,确保患者全疗程规范用药。Objective To analyze the difference in the use of free fixed dose combination(FDC),and indirect evaluation of the rationality of anti-tuberculosis drug use before and after transformation of new TB prevention and control service mode in Chongqing from 2015 to 2019,it can provide reference for drug demand measurement,procurement,distribution,use and supervision.Methods We used China Information System for Disease Control and Prevention to obtain the number of TB patients,the quarterly reports of anti-tuberculosis drug distribution and other data registered in 2015-2019,and calculated the annual theoretical consumption and actual consumption of FDC-HRZE and FDC-HR respectively,and then utilizing the calculation formula of the difference in the use of drugs,checked the FDC use verification difference of Chongqing city and its four regions.Results From 2015 to 2019,the average differences of FDC-HRZE and FDC-HR in Chongqing were-43.70%and-31.34%,respectively.The main urban area were-52.91%and-45.38%,the metropolitan area were-39.01%and-24.51%,the town group of the three gorges reservoir area in Northeast Chongqing were-42.00%and-30.75%,the town group of Wuling mountain area in Southeast Chongqing were-47.73%and-29.25%,respectively,all beyond the set range of±25%.After the transformation of new TB prevention and control service mode,the average differences of FDC-HRZE and FDC-HR were-22.19%and-21.36%in 2018,and-21.65%and-16.43%in 2019,respectively,both in the set range of±25%.And the average differences of FDC-HRZE,and FDC-HR of the main urban area in 2018 were-29.90%,-36.36%and-29.69%,-11.67%in 2019;the metropolitan area-20.34%,-20.54%in 2018 and-8.73%,-0.19%in 2019;the town group of the three gorges reservoir area in Northeast Chongqing were-18.51%,-17.07%in 2018 and-19.72%,-21.36%in 2019;the town group of Wuling mountain area in Southeast Chongqing were-26.54%,-11.47%in 2018 and-54.10%,-56.45%in 2019,respectively.Conclusions In recent years,the administration of free anti-tuberculosis drugs in our city had achiev

关 键 词：结核病 免费抗结核药品 转型 使用分析 

分 类 号：R521[医药卫生—内科学]