麻布七中1个新的二萜类生物碱  

One new diterpenoid alkaloid from Aconitum sinomontanum

作　　者：王菲 张娇[2] 李玉泽 张东东[2] 张化为[2] 黄文丽[2] 罗定强 宋小妹 WANG Fei;ZHANG Jiao;LI Yu-ze;ZHANG Dong-dong;ZHANG Hua-wei;HUANG Wen-li;LUO Ding-qiang;SONG Xiao-mei(Shaanxi Institute for Food and Drug Control,Xi’an 710065,China;School of Pharmacy,Shaanxi University of Chinese Medicine,Xianyang 712046,China)

机构地区：[1]陕西省食品药品监督检验研究院,陕西西安710065 [2]陕西中医药大学药学院,陕西咸阳712046

出　　处：《中草药》2021年第3期626-629,共4页Chinese Traditional and Herbal Drugs

基　　金：陕西中医药大学学科创新团队项目(2019-YL12)。

摘　　要：目的研究麻布七Aconitum sinomontanum的化学成分。方法采用硅胶柱色谱、半制备型高效液相色谱进行分离纯化,通过理化性质及现代波谱技术鉴定化合物的结构。结果从麻布七的80%乙醇提取物中分离得到3个二萜类生物碱,分别鉴定为1α,11α,15β-trihydroxylatisine(1)、demethylenedelcorine(2)、denudatine(3)。结论化合物1为新化合物,命名为光翠雀碱B,化合物3为首次从该植物中分离得到。Objective To investigate the diterpenoid alkaloids from the roots of Aconitum sinomontanum.Methods The 80%ethanol extract from A.sinomontanum was isolated and purified by silica and semi-preparative HPLC column.Then the structures of obtained compounds were identified by physicochemical properties and spectral data.Results Three compounds were isolated and their structures were identified as 1α,11α,15β-trihydroxylatisine(1),demethylenedelcorine(2),and denudatine(3),respectively.Conclusion Compound 1 is a new compound named denudatine B,and compound 3 is isolated from this plant for the first time.

关 键 词：麻布七 二萜类生物碱 光翠雀碱B 1α 11α 15β-trihydroxylatisine denudatine 

分 类 号：R284.1[医药卫生—中药学]