阿格列汀对糖尿病合并冠心病患者胰岛抵抗及leptin ET-1 ICAM-1的影响  

The effect of Alogliptin on insulin resistance and serum leptin,plasma ET-1,ser-um ICAM-1 in patients with diabetes mellitus complicated with coronary heart disease

作　　者：丁燕萍[1] 鲜廉杰[1] 王翼华[1] 崔建蕾[1] Ding Yanping;Xian Lianjie;Wang Yihua;Cui Jianlei(Nanyang First Peoples Hospital,Nanyang 473010,Henan,China)

机构地区：[1]南阳市第一人民医院,河南南阳473010

出　　处：《临床心身疾病杂志》2020年第1期13-16,44,共5页Journal of Clinical Psychosomatic Diseases

摘　　要：目的探讨阿格列汀对糖尿病合并冠心病患者胰岛抵抗及血清瘦素、血浆内皮素-1、血清血管细胞间粘附分子-1水平的影响.方法将128例糖尿病合并冠心病患者按照随机数字表法分为观察组与对照组,每组64例.两组均给予冠心病常规治疗方案治疗,口服胰岛素控制血糖,观察组在此基础上给予阿格列汀薄膜衣片治疗,对照组给予黄色薄膜衣片安慰剂治疗,观察3个月.比较两组治疗后血糖控制合格率及冠心病临床症状改善情况,比较两组治疗前后空腹血糖及胰岛素抵抗指数及血清瘦素、血浆内皮素-1、血清血管细胞间粘附分子-1水平变化情况,比较两组不良反应发生率.结果观察组血糖控制合格率显著高于对照组(P<0.01),心绞痛发作次数显著少于对照组(P<0.01),Duke运动耐量评分显著高于对照组(P<0.01).治疗1个月起两组空腹血糖及胰岛素抵抗指数均较治疗前显著下降(P<0.01),观察组较对照组下降更显著(P<0.01).治疗1个月起两组血清瘦素、血浆内皮素-1、血清血管细胞间粘附分子-1水平均较治疗前显著下降(P<0.01),观察组较对照组下降更显著(P<0.01).两组患者不良反应发生率比较差异无统计学意义(P>0.05).结论阿格列汀治疗糖尿病合并冠心病患者效果显著,能有效控制血糖及冠心病临床症状,显著降低血清瘦素、血浆内皮素-1、血清血管细胞间粘附分子-1水平.Objective To analyze the effect of Alogliptin on insulin resistance and serum leptin,plasma ET-1,serum ICAM-1 in patients with diabetes mellitus complicated with coronary heart disease.Methods 128 patients with diabetes mellitus complicated with coronary heart disease were divided into observation group and control group according to the random number table method,64 cases in each group.Both groups were given conventional treatment for coronary heart disease,and oral insulin to controll blood sugar.On the basis of this,the observation group was treated with alogliptin film,and the control group was given yellow film-coated placebo for 3 months.Compare the qualified rate of blood glucose control and the improvement of clinical symptoms of coronary heart disease in the two groups after treatment.The fasting blood glucose and insulin resistance index and the changes of plasma ET-1,serum ICAM-1,serum ICAM-1 levels were compared before and after treatment.The incidence of adverse reactions was compared between the two groups.Results The blood glucose control rate of the observation group was significantly higher than that of the control group(P<0.01).The number of angina attacks was significantly less than that of the control group(P<0.01),and the Duke exercise tolerance score was significantly higher than the control group(P<0.01).After 1 month of treatment,the fasting blood glucose and insulin resistance index of the two groups were significantly lower than those before treatment(P<0.01),and the observation group decreased more significantly than the control group(P<0.01).After 1 month of treatment,serum leptin,plasma ET-1 and serum ICAM-1 levels were significantly lower than those before treatment(P<0.01).The observation group decreased more significantly than the control group(P<0.01).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions Alogliptin is effective in the treat-ment of diabetic patients with coronary heart disease,it can effectively contro

关 键 词：糖尿病 冠心病 阿格列汀 瘦素 内皮素-1 血管细胞间粘附分子-1 

分 类 号：R587.1[医药卫生—内分泌] R541.4[医药卫生—内科学]