微发泡工艺与材料配比对聚己内酯/聚乳酸共混材料微发泡行为的影响  

Effect of Foaming Process and Material Proportion on Microcellular Foaming Behavior of Polycaprolactone/Polylactic Acid Blends

作　　者：王利霞[1,2] 周露 富学宇 王东方[1,2] 赵幸一 周诣平 李倩[1,2] 申长雨[2] Lixia Wang;Lu Zhou;Xueyu Fu;Dongfang Wang;Xingyi Zhao;Yiping Zhou;Qian Li;Changyu Shen(School of Mechanics and Safety Engineering,Zhengzhou University;National International JointResearch Center for Micro-Nano Moulding Technology,Zhengzhou University,Zhengzhou 450001,China)

机构地区：[1]郑州大学力学与安全工程学院 [2]郑州大学微纳成型技术国家级国际联合研究中心,河南郑州450001

出　　处：《高分子材料科学与工程》2020年第12期1-6,共6页Polymer Materials Science & Engineering

基　　金：国家自然科学基金资助项目(11372287);河南省科技攻关项目(国际科技合作)(172102410061)。

摘　　要：可生物降解聚合物多孔支架已成为组织工程的研究热点。文中采用超临界CO2微发泡技术,对聚乳酸(PLA)与聚己内酯(PCL)共混材料进行发泡,并分析了发泡工艺、材料配比对PCL/PLA共混体系泡孔形态的影响。实验结果表明,随着保压压力的升高,泡孔直径减小、泡孔密度增加;随着发泡温度的升高,泡孔直径增大、泡孔密度减小;随着保压时间的延长,泡孔直径增大、泡孔密度略有降低,最终趋于稳定。泡孔直径和泡孔密度决定着开孔度的大小。随着PLA含量的增加,PCL/PLA共混体系的泡孔密度增大,泡孔直径减小。Biodegradable polymer porous scaffolds have become the research focus of tissue engineering.The microcellular materials of polylactic acid(PLA)and polycaprolactone(PCL)blends were fabricated and investigated through supercritical carbon dioxide foaming technology.The influence of process parameters and material proportions on the cell morphology was analyzed.The SEM results indicate that the increase of saturation pressure leads to the decrease of cell size and the increase of cell density.With the increase of saturation temperature,the average cell size increases,the cell density decreases significantly.With the increase of saturation time,the average cell size increases,the cell density decreases slightly,and both of them tend to be stable completely.The open-cell content depends on the comprehensive effect of average cell size and cell density.With the increase of PLA content of the PCL/PLA blends,the cell density increases,and the average cell size decreases.

关 键 词：微发泡 聚己内酯/聚乳酸共混 工艺条件 泡孔形态 

分 类 号：R318.08[医药卫生—生物医学工程]