注射用头孢哌酮钠舒巴坦钠致喉头水肿一例  

A case report of laryngeal edema caused by cefoperazone sodium and sulbactam sodium

作　　者：罗柳金[1] 李碧青[1] LUO Liu-jin;LI Bi-qing(Department of Pharmacy,TheSecond Affiliated Hospital of Guangzhou Medical University,Guangzhou 511447,China)

机构地区：[1]广州医科大学附属第二医院药剂科,广州511447

出　　处：《中国处方药》2021年第3期63-64,共2页Journal of China Prescription Drug

摘　　要：1例30岁男性患者因"慢性阻塞性肺疾病急性加重"、"肺大泡"入院,静脉滴注头孢哌酮钠舒巴坦钠(舒普深)抗感染治疗,输注5 min后,患者出现呼吸困难,大汗淋漓,血氧进行性下降,呼吸道分泌物增加,咽喉不适,查喉头水肿,考虑舒普深致过敏反应。立即停止输注舒普深,更换0.9%氯化钠注射液静脉滴注,更换输液器。同时给予中流量吸氧,静脉推注甲强龙,雾化吸入复方异丙托溴铵及布地奈德混悬液,静脉滴注多索茶碱。患者于1 h后病情转稳定,喉头水肿减轻,呼吸逐渐平顺,神志清,血压、脉搏、呼吸恢复正常。临床使用药物时需特别关注头孢哌酮钠舒巴坦钠的严重不良反应。A 30-year-old man was hospitalized for COPD and lung bullae.Because of treating infection,he was infused cefoperazone sodium and sulbactam sodium(sulperazon).But 5 minutes later,he showed not only dyspnea,sweating,decreasing oxygen saturation,but also increasing respiratory secretions,throat discomfort and laryngeal edema.The doctor considered hypersensitivity caused by sulperazon.Stopped infusing the sulperazon immediately,and replaced it by 0.9%NS or new infusion device as soon as possible.At the same time,took medicine to rescue for the patient,included adopting medium flow inhale oxygen,pushing solu medrol,atomizing combivent and pulmicort respules,furthermore dripping doxofylline.Based on all emergency salvages,laryngeal edema was alleviated,the vital signs of patient returned to normal after 1-hour.Therefore,the doctors needed to pay more attention to the serious adverse events of cefoperazone sodium and sulbactam sodium.

关 键 词：头孢哌酮钠舒巴坦钠 喉头水肿 药物不良反应 

分 类 号：R969.3[医药卫生—药理学]