自拟平哮汤治疗对支气管哮喘急性发作期患者外周血嗜酸粒细胞及IgE水平的影响  

Effects of Pingxiao Decoction on eosinophils and IgE in peripheral blood of patients with acute stage of bronchial asthma

作　　者：付佑辉[1] 游鸿[1] 池峰[1] 蔡峰[1] 白冲 戈霞晖 FU You-hui;YOU Hong;CHI Feng(Department of Respiratory,The Seventh People's Hospital of Shanghai University of TCM,Shanghai 200137 China)

机构地区：[1]上海中医药大学附属第七人民医院呼吸内科,上海200137

出　　处：《中国处方药》2021年第3期142-144,共3页Journal of China Prescription Drug

基　　金：国家自然科学基金(81300018);上海市浦东新区科技发展基金民生科研专项资金医疗卫生项目(PKJ2019-Y13)。

摘　　要：目的评价自拟平哮汤治疗支气管哮喘(简称哮喘)急性发作期的临床疗效、外周血嗜酸性粒细胞及IgE水平。方法将62例符合纳入标准患者随机分为治疗组32例和对照组30例。对照组采用布地奈德福莫特罗吸入剂及多索茶碱等药物治疗,治疗组在对照组的基础上加服自拟平哮汤。两组均4 d为1个疗程,共3个疗程。观察两组有效率、缓解时间、中医证候及最大呼气峰流速PEF、EOS、IgE指标。结果治疗组总有效率为96.88%,第1疗程临床症状两组均有缓解,治疗组优于对照组(P<0.05);治疗组患者在第1疗程后PEF、EOS、IgE均较治疗前改善(P<0.05);治疗组中患者的PEF、EOS、IgE改善较对照组明显,差异具有统计学意义(P<0.05)。结论自拟平哮汤联合解痉平喘等药物治疗哮喘,能明显改善哮喘急性发作临床症状,缩短治疗时间,改善中医证候及PEF、EOS、IgE,效果明显优于单纯西药治疗。Objective To evalutation Pingxiao decoction effect on acute stage of bronchial asthma,eosinophils and IgE levels in the treatment of with the combination of traditional Chinese and Western medicine.Methods 62 patients were randomly divided into treatment group(32 cases)and control group(30 cases).The control group was treated with budesonide and doxofylline,while the treatment group was treated with self-made Pingxiao Decoction on the basis of the control group.Two groups were 4 days for a course of treatment,a total of 3 courses.The clinical efficacy,remission time,TCM syndromes and PEF,EOS,IgE of the two groups were observed.Results The total effective rate of the treatment group was 96.88%,the first course of clinical symptoms of the two groups were relieved,the treatment group was better than the control group(P<0.05);PEF,EOS,IgE were improved or significantly improved after treatment(P<0.05);the improvement of the treatment group was significantly better than the control group(P<0.05).Conclusion The self-designed Pingxiao decoction combined with antispasmodic and antiasthmatic treatment can significantly improve the clinical symptoms of acute asthma attack,shorten the treatment time,improve the TCM syndrome and PEF,EOS,IgE,and the effect is significantly better than that of Western medicine alone.

关 键 词：平哮汤 支气管哮喘 血嗜酸性粒细胞 IGE 

分 类 号：R562.25[医药卫生—呼吸系统]