新冠肺炎轻症患者治愈标准及核酸检测假阴性的思考和解决方案  

Cure criteria for COVID-19 patients with mild symptoms and false negative cases in nucleic acid tests:a discussion on solutions

作　　者：沈健[1] 王韬 单强 刘中民[2] SHEN Jian;WANG Tao;SHAN Qiang;LIU Zhongmin(Department of Nephrology,Shuguang Hospital of Shanghai Traditional Chinese Medicine College,Shanghai 201203,China;China East Hospital of Tongji University,Shanghai 200120,China)

机构地区：[1]上海中医药大学附属曙光医院肾脏科,上海201203 [2]同济大学附属东方医院,上海200120

出　　处：《中华灾害救援医学》2021年第3期841-843,847,共4页Chinese Journal of Disaster Medicine

摘　　要：目的本文旨在通过研讨方舱医院收治轻型冠状病毒肺炎患者治愈标准进行思考探究轻症患者的治愈标准。方法通过标本采集标准化培训、提高试剂盒质控、核酸检测做为初筛标准,增加抗原抗体检测明确性质、做好出院患者随访等方式减少核酸假阴性可能,提高治愈标准。结果通过上述方法,对于提高轻症患者的治愈标准存在明显意义。结论相较于重症、危重症或者普通型患者,方舱医院的轻症患者的出院标准不妨更为严格一些,并需要进一步明确出院后的强制居家隔离要求,特别是增加出院后的核酸复查。Objective This paper explores the cure criteria of COVID-19 patients with mild symptoms with our experience from mild-symptom patients in makeshift hospitals.Methods We were able to reduce possible false negative cases in nucleic acid testing and establish better criteria for cure by providing training in a standardized sample collection procedure,improving the quality control of test kits,using nucleic acid testing as the initial screening criteria,and using antigen/antibody testing to further investigate each case.We followed up discharged patients carefully to check whether there were any false negative cases among them.Results Stricter cure criteria for patients with mild symptoms will achieve a significantly better result.Conclusion Compared with serious,critical,or common cases,we may adopt stricter discharge criteria for patients with mild symptoms in makeshift hospitals.We recommend further clarifying requirements for compulsory home isolation after discharge.In particular,we should perform nucleic acid testing for discharged patients.

关 键 词：核酸检测 假阴性 标本采集 治愈标准 

分 类 号：R446[医药卫生—诊断学]