清宣止咳颗粒治疗儿童感冒风热证临床研究  

Clinical study of Qingxuan Zhike Granules in the treatment of children with cold of wind-heat syndrome

作　　者：杜丽娜[1] 杨燕[1] 牟青慧 袁斌 张金虎[4] 赵鋆[5] 吴力群[6] 郑敏[7] 徐勇胜[8] 汪受传 DU Li-na;YANG Yan;MOU Qing-hui;YUAN Bin;ZHANG Jin-hu;ZHAO Jun;WU Li-qun;ZHENG Min;XU Yong-sheng;WANG Shou-chuan(National Center of Children's Health,Beijing Children's Hospital,Capital Medical University,Beijing 100045,China;Oilu Children's Hospital,Shangdong University,Jinan 250022,China;Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210023,China;Xi'an Children's Hospital,Xi'an 710003,China;Shuguang Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200021,China;Dongfang Hospital,Beijing University of Chinese Medicine,Beijing 100078,China;Shenzhen Hospital of Traditional Chinese Medicine,Shenzhen 518034,China;Tianjin Children's Hospital,Tianjin 300074,China)

机构地区：[1]国家儿童医学中心,首都医科大学附属北京儿童医院,北京100045 [2]山东大学齐鲁儿童医院,济南250022 [3]南京中医药大学附属医院,南京210023 [4]西安市儿童医院,西安710003 [5]上海中医药大学附属曙光医院,上海200021 [6]北京中医药大学东方医院,北京100078 [7]深圳市中医院,深圳518034 [8]天津市儿童医院,天津300074 [9]南京中医药大学附属医院儿科,南京210023

出　　处：《中华中医药杂志》2021年第2期1157-1160,共4页China Journal of Traditional Chinese Medicine and Pharmacy

摘　　要：目的:观察清宣止咳颗粒治疗儿童感冒风热证的临床疗效。方法:将211例感冒风热证患儿按照多中心、区组随机、平行对照的原则分为试验组108例和对照组103例。试验组给予清宣止咳颗粒治疗,对照组给予小儿宝泰康颗粒治疗,两组疗程均为5d。比较两组患儿治疗前后主要症状(发热)、次要症状(鼻塞流涕、恶风、喷嚏、咳嗽、痰液、咽部、面色、头痛、哭闹烦躁、口渴、小便)积分并判定临床疗效。结果:试验组痊愈率为55.56%(60/108),总有效率为98.15%(106/108);对照组痊愈率为36.89%(38/103),总有效率为98.06%(101/103),试验组痊愈率优于对照组(P<0.05)。两组治疗后主要症状、次要症状积分均较治疗前显著降低(P<0.05),且试验组次要症状咳嗽、痰液、咽部改变积分及次要症状总积分较对照组显著降低(P<0.05)。结论:清宣止咳颗粒可有效改善儿童感冒风热证的临床症状,尤其对咳嗽、痰液、咽部症状改善效果明显。Objective:To observe therapeutic effect of Qingxuan Zhike Granules in the treatment of children with cold of wind-heat syndrome.Methods:A total of 211 cases of children with cold of wind-heat syndrome were randomly divided into test group(108 cases)and control group(103 cases)according to the principle of multi-center,block-randomized,parallel controlled.The test group was treated with Qingxuan Zhike Granules while the control group was given Xiaoer Baotaikang Granules.The course of treatment was 5 days.Scores of main symptom(fever)and secondary symptoms(including nasal congestion,aversion to wind,sneezing,cough,sputum,pharyngeal change,complexion,headache,crying and fidgeting,thirst,complexion,urine)in two groups before and after treatment were compared.And the clinical curative effect was also evaluated.Results:The cure rate of the test group was 55.56%(60/108)with the total effective rate was 98.15%(106/108);the cure rate of the control group was 36.89%(38/103),the total effective rate was 98.06%(101/103).There was statistical significance in difference of cure rate between two groups(P<0.05).The main symptoms and secondary symptom scores of the two groups were significantly lower than those before treatment(P<0.05).Moreover,the scores of secondary symptoms including cough,sputum,pharyngeal change and total scores of secondary symptoms was significantly lower than those in the control group,and the difference was statistically significant(P<0.05).Conclusion:Qingxuan Zhike Granules can effectively improve the clinical symptoms of children with cold of wind-heat syndrome,especially for cough,sputum and pharyngeal symptoms.

关 键 词：感冒 清宣止咳颗粒 儿科 

分 类 号：R272[医药卫生—中医儿科学]