辣椒素受体在针刺促进白色脂肪褐变中的作用  

Effects of TRPV1 in promoting white adipose tissue browning by acupuncture

作　　者：汤倩倩 徐斌[1] 袁锦虹[1] 景欣悦[1] TANG Qian-qian;XU bin;YUAN Jin-hong;JING Xin-yue(Key Laboratory of Acupuncture and Medicinc Research of Minister of Education,Nanjing University of Chinese Medicine,Nanjing 210023,China)

机构地区：[1]南京中医药大学针药结合教育部重点实验室,南京210023

出　　处：《中华中医药杂志》2021年第1期338-341,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：江苏省高校自然科学基金重大项目(No.17KJA360001)。

摘　　要：白色脂肪组织(WAT)褐变是肥胖机体能量代谢的途径之一。辣椒素受体(TRPV1)广泛存在于多种代谢活跃的组织中,通过多个途径参与褐变,包括:细胞内增加钙离子内流,阻止脂肪细胞生成;刺激细胞代谢;TRPV1激活sirt1依赖的PPARγ去乙酰化,促进PPARγ与prdm16的相互作用进而促使褐变。而针刺能显著提高肥胖小鼠WAT的UCP1、PGC-1α、prdm16、sirt1等这些BAT特异性蛋白的表达水平,促进PPARγ去乙酰化水平和WAT的脂质分解,达到褐变的效果。TRPV1参与针刺减肥的可能途径或参与了针刺信号的启动,或通过激活TRPV1通道促使褐变发生。The browning of white adipose tissue(WAT)offers an innovative opportunity to tackle obesity.TRPV1 not only widely distributes in various tissues that metabolize actively,but participates in browning of WAT via the following ways:Increasing intracellular calcium influx;stimulating cell metabolism;activating sirt1-depentant deacetylation of PPARγand facilitating PPARγ-prdm16 interaction,which promotes browning of WAT.Whereas acupuncture can significantly improve the expression of UCP1,PGC-1α,prdm16,sirt1(brown adipose tissue-related proteins)in the WAT of high-fat diet mice,moreover enhance the deacetylation of PPARγand the lipolysis of WAT,which makes WAT browning.In the process of acupuncture combating obesity,TRPV1 may be involved in the initiation of acupuncture signal and activate WAT browning.

关 键 词：针刺 辣椒素受体 肥胖 白色脂肪组织褐变 

分 类 号：R245[医药卫生—针灸推拿学]