脊髓型颈椎病动物模型的研究现状  

Research status of animal models of cervical spondylotic myelopathy

作　　者：银河[1,2,3] 陈琳 陈忻 金哲峰[1,2,3] 尹逊路[1,2,3] 朱立国[1,2,3] YIN He;CHEN Lin;CHEN Xin;JIN Zhe-feng;YIN Xun-lu;ZHU Li-guo(Wangijing Hospital of China Academy of Chinese Medical Sciences,Bcijing 100102,China;Beijing Institute ofOrthopedics of Integrated Traditional Chinesce and Western Medicine,Bcijing 100700,China;Beijing Key Laboratory of Bonc Setting Technology of Traditional Chinese Medicine,Beijing 100700,China;Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]中国中医科学院望京医院,北京100102 [2]北京市中西医结合骨伤研究所,北京100700 [3]中医正骨技术北京市重点实验室,北京100700 [4]北京中医药大学,北京100029

出　　处：《中华中医药杂志》2021年第1期354-357,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金项目(No.81904232);国家中医药管理局行业专项课题(No.201407001-11);中国中医科学院名贵中药资源可持续利用能力建设项目(No.2060302),中国中医科学院中央级公益性科研院所基本科研业务费自主选题(No.ZZ11-082)。

摘　　要：为系统分类并评价现存脊髓型颈椎病(CSM)动物模型的模式动物、造模方法,以期为CSM的动物实验研究提供参考和依据。通过检索各数据库中有关CSM动物实验的权威杂志期刊,以动物模型质量评价的六大原则为依据,系统总结并评价当前CSM动物模型的现状。笔者发现当前构建CSM动物模型的模式动物种类较多、造模方法多样,但都存在一定程度的不足,需基于前期基础不断探索和优化当前CSM动物模型,以期构建一种理想的CSM动物模型。In order to systematically classify and evaluate the existing animal models of cervical spondylotic myelopathy(CSM), and to provide reference and basis for the animal experimental study of CSM. Based on the six principles of animal model quality evaluation, the current situation of CSM animal models was systematically summarized and evaluated by searching the authoritative journals about CSM animal experiments in various databases. The authors found that there are many kinds of model animals and various modeling methods to build CSM animal models, but there are some shortcomings. We need to explore and optimize the current CSM animal models based on the previous basis, in order to build an ideal CSM animal model.

关 键 词：脊髓型颈椎病 动物模型 研究现状 

分 类 号：R681.5[医药卫生—骨科学] R-332[医药卫生—外科学]