Modular Total Synthesis of (-)-Palmyrolide A and (+)-(5S,7S)-Palmyrolide A via Ring-Closing Metathesis and Alkene Isomerization  

作　　者：Yecai Lai Wei-Min Dai 

机构地区：[1]Laboratory of Advanced Catalysis and Synthesis,Department of Chemistry and Hong Kong Branch of the Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou),The Hong Kong University of Science and Technology,Clear Water Bay,Kowloon,Hong Kong SAR,China [2]Baiyunshan Pharmaceutical General Factory,Guang-zhou Baiyunshan Pharmaceutical Holdings Co.,Ltd.,Guangzhou 510515,China

出　　处：《Chinese Journal of Chemistry》2021年第1期69-74,共6页中国化学（英文版）

基　　金：This work is supported in part by a General Research Fund grant(601211)from the Research Grant Council;The Hong Kong Special Administrative Region,P.R.China;The Hong Kong Chiu Chow Chamber of Commence HKUST Scholarship for Ph.D.Study(Y.L.);the Department of Chemistry,HKUST.

摘　　要：A pentamodule assembly approach has been established for total synthesis of the naturally occurring(-)-palmyrolide A and(+)-5,7-epi-palmyrolide A.By using the racemic tert-butyl carbinol-containing alkyl iodide,the two diastereoisomeric macrolides could be obtained from the same sequence of reactions,demonstrating the flexibility of the multimodule assembly strategy for diverted total synthesis.

关 键 词：ALKENE B-Alky Suzuki-Miyaura cross-coupling Modular total synthesis Cross coupling Ring-closing metathesis 

分 类 号：O62[理学—有机化学]