Sarcaglarols A-D, Lindenane-Monoterpene Heterodimers from Sarcandra glabra Based on Molecular Networks  

作　　者：Yongyue Wang Zhirong Cui Jun Chi Pengfei Tang Meihui Zhang Jixin Li Yongyi Li Hao Zhang Jun Luo Lingyi Kong 

机构地区：[1]Jingsu Key laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines,School of Taditional Chinese Pharmacy,China Pharmaceutical University,Nanjing,Jiangsu 210009,China

出　　处：《Chinese Journal of Chemistry》2021年第1期129-136,共8页中国化学（英文版）

基　　金：Financial support for this study is from the"Double First-Class"University project(CPU2018GY08,China);the 111 Project from Ministry of Education of China and the State Administration of Foreign Export Affairs of China(B18056);the National New Drug Innovation Major Project(2018ZX09711-001-007).

摘　　要：Sarcaglarols A-D(1-4),two pairs of lindenane-monoterpene heterodimers fused by a 1,2-dioxane moiety,were discovered and isolated from the leaves of Sarcandra glabra guided by MS/MS molecular networking-based strategy.Their planar structures,absolute configurations of basic skeleton and flexible polyhydric side chain were established by analysis of HRESIMS,NMR spectroscopic data,ECD spectrum,and the X-ray diffraction study of isopropylidene derivatives.An intermolecular[2+2+2]cycloaddition may play a key role in the biosynthesis pathway of the 1,2-dioxane moiety fused lindenane-monoterpene heterodimer skeleton,which can be recognized as the biogenetic precursors of our previous reported lindenane-normonoterpene conjugates.In addition,compounds 1,3 and 4 exhibited moderate inhibitory effects of lipid accumulation in free fatty acid-exposed L02 cells.

关 键 词：Sarcandra glabra Molecular networks Natural products Structural elucidation PEROXIDES 

分 类 号：O62[理学—有机化学]