自体PRP治疗KOA的疗效及对相关介质的影响  

作　　者：李悦[1] 沈斌 陈利宁 倪向明 徐仲翔 吴峰淼 吕存贤[1] 

机构地区：[1]浙江省温州市中医院,325000

出　　处：《浙江临床医学》2021年第3期380-382,共3页Zhejiang Clinical Medical Journal

基　　金：温州市卫生健康委员会项目(2019ZB002);浙江省医药卫生科技计划项目(2020KY296)。

摘　　要：目的探讨关节腔内注射自体富血小板血浆(PRP)治疗膝骨性关节炎(KOA)的疗效及其对相关介质的影响。方法选取2016年7月至2019年3月温州市中医院收治的KOA患者100例,按随机数字表法分为观察组和对照组,每组各50例,两组患者基础治疗相同,观察组同时采用关节腔内注射自体PRP治疗,比较两组治疗前后的膝关节功能状态及实验室检查指标水平,并进行疗效评估。结果治疗3个月、6个月后,两组膝关节功能评分比较,观察组WOMAC评分低于对照组,而Lysholm评分高于对照组。治疗6个月后,观察组血清MMP3、TIMP-1、PGE2、SP、LTB4、LTC4测定值均低于对照组(P<0.05)。两组患者疗效比较,观察组显效率(64%)明显高于对照组(44%),差异有统计学意义(P<0.05)。结论关节腔内注射PRP治疗KOA可以改善患者症状、降低骨关节炎相关介质水平,临床效果满意。Objective To explore the effect of intra-articular injection of autologous platelet-rich plasma(PRP)on knee osteoarthritis(KOA)and its influence on related mediators.Methods A total of 100 KOA patients admitted to Wenzhou Hospital of Traditional Chinese Medicine from July 2016 to March 2019 were selected and divided into observation group and control group according to the random number table method,with 50 cases in each group.The basic treatment of the two groups was the same,and the observation group was at the same time Intra-articular injection of autologous PRP was used to compare the functional status of the knee joints before and after the treatment and the level of laboratory test indicators,and the efficacy was evaluated.Results After 3 months and 6 months of treatment,the knee joint function scores of the two groups were compared.The WOMAC score of the observation group was lower than that of the control group,while the Lysholm score was higher than that of the control group.After 6 months of treatment,the measured values of serum MMP3,TIMP-1,PGE2,SP,LTB4,and LTC4 in the observation group were lower than those in the control group(P<0.05).The efficacy of the two groups of patients were compared,the observation group's significant rate(64%)was significandy higher than that of the control group(44%),and the difference was statistically significant(P<0.05).Conclusion Intra-articular injection of PRP in the treatment of KOA can improve patients'symptoms and reduce the level of osteoarthritis-related mediators,and the clinical effect is positive.

关 键 词：富血小板血浆 骨性关节炎 基质金属蛋白酶3 基质金属蛋白酶抑制物-1 

分 类 号：R68[医药卫生—骨科学]