潍坊地区妊娠中期孕妇维生素D状况及影响因素  

Vitamin D status and its impact factors in the second trimester of pregnancy in Weifang area

作　　者：王兰玲[1] 张春磊[2] 牟莹莹[1] 王执勇[3] WANG Lan-ling;ZHANG Chun-lei;MOU Ying-ying;WANG Zhi-yong(Obstetrics Department,Weifang Maternal and Child Health Hospital,Weifang 261011,Shandong,China;Neonatology Department,Weifang Maternal and Child Health Hospital,Weifang 261011,Shandong,China;Pediatric Department,Weifang Maternal and Child Health Hospital,Weifang 261011,Shandong,China)

机构地区：[1]潍坊市妇幼保健院产科,山东潍坊261011 [2]潍坊市妇幼保健院新生儿科,山东潍坊261011 [3]潍坊市妇幼保健院儿科,山东潍坊261011

出　　处：《中华骨质疏松和骨矿盐疾病杂志》2021年第1期9-15,共7页Chinese Journal Of Osteoporosis And Bone Mineral Research

基　　金：山东省医药卫生科技发展计划(2018WS093);潍坊市卫生计生委科研项目(wfwsjs_2018_031)。

摘　　要：目的调查潍坊地区妊娠中期孕妇维生素D状况,并分析与维生素D缺乏相关的因素。方法选取2016年9月至2017年8月在潍坊市妇幼保健院定期产检的孕妇为研究对象,应用液相色谱-串联质谱(liquid chromatography-tandem mass spectrometry,LC-MS/MS)方法测定妊娠中期孕妇血清25羟-维生素D(25 hydroxyvitamin D,25OHD)浓度。调查问卷收集孕妇的一般资料和近3个月生活方式。结果检测1643名孕妇血清中25OHD浓度结果显示,25OHD浓度为21.50(15.50,29.90)μg/L,维生素D缺乏率为45.34%。Logistic回归分析显示,季节、维生素D补充剂、户外活动、阳光喜好等因素与维生素D缺乏显著相关(Ps<0.05)。结论潍坊地区孕中期妇女维生素D缺乏率较高,且呈季节变化趋势,夏季低,冬季高。维生素D缺乏高风险的孕妇宜进行产前25OHD检测,并通过增加阳光照射、应用维生素D补充剂和增加户外运动等方式降低风险。Objective To investigate vitamin D status of women at the second trimester of pregnancy living in Weifang area,Shandong Province,and to analyze the factors related to vitamin D deficiency.Methods The mid-trimester pregnant women who were regularly examined in Weifang Maternal and Child Health Hospital from September 2016 to August 2017 were enrolled into the study.The liquid chromatography tandem-mass spectrometry(LC-MS/MS)was applied to determine serum 25-hydroxy-vitamin D(25OHD)concentration of the pregnant women.Their basic information and recently three-month lifestyle were collected through questionnaires.Results A total of 1643 pregnant women were enrolled and then 25OHD concentration were tested.The results indicated that the median(P25,P75)of 25OHD concentration was 21.50(15.50,29.90)μg/L,and the prevalence of vitamin D deficiency was 45.34%.Logistic regression analysis showed that season,vitamin D supplements,outdoor activities,and sunshine preferences were significantly related to vitamin D deficiency(Ps<0.05).Conclusion The prevalence of vitamin D deficiency in women at the second trimester of pregnancy in Weifang area is high,and it changes seasonally,lower in summer and higher in winter.The pregnant women with high risk of vitamin D deficiency should increase sun exposure,vitamin D supplements,and outdoor exercise.

关 键 词：25-羟维生素D 维生素D 妊娠中期 潍坊 

分 类 号：R714.7[医药卫生—妇产科学]