膜蛋白FKBP38病理生理功能研究进展  

Research Progress of Pathophysiological Functions of Membrane Protein FKBP38

作　　者：尚画雨 夏志[2] SHANG Huayu;XIA Zhi(Chengdu Sport University,Chengdu 610041,China;Jinggangshan University,Ji’an 343009,China)

机构地区：[1]成都体育学院,四川成都610041 [2]井冈山大学,江西吉安343009

出　　处：《中国体育科技》2021年第2期82-88,共7页China Sport Science and Technology

基　　金：国家自然科学基金青年基金项目(31900842);四川省应用基础研究项目(2019YJ0544);江西省自然科学基金面上项目(20192BAB205081);江西省教育厅科技项目重点项目(GJJ180560)。

摘　　要：FKBP38亦称FKBP8,在诸多方面均体现其为FK506结合蛋白家族的一个特殊成员,仅FKBP38具有对钙调蛋白的调节活性。FKBP38活化还可通过抑制抗凋亡Bcl-2参与凋亡信号传导。研究表明,除在程序性细胞死亡中的作用外,FKBP38还发挥对诸多差异显著的细胞过程的调控作用,而这些过程不完全依赖其FKBP结构域。FKBP38的生物学功能包括调节蛋白激酶mTOR、介导线粒体自噬、调节细胞缺氧反应以及丙型肝炎病毒复制等。因此,FKBP38的药理学靶向作用研究极可能是一种有效干预对FKBP38不同依赖性过程(如癌症或神经退行性疾病的程序性细胞死亡)的策略。FKBP38,also known as FKBP8,which is a special member of the FK506 binding protein family in many aspects.Only FKBP38 has calmodulin-regulated activity in this protein family.The activation of FKBP38 also participates in apoptotic signal transduction by inhibiting the anti-apoptotic Bcl-2.It has been shown that besides the above-mentioned programmed cell death,FKBP38 also plays a regulatory role in many distinct cell processes,which do not depend entirely on the FKBP domain.The biological functions of FKBP38 include regulation of the kinase m TOR,regulation of mitophagy,regulation of cellular hypoxia response and hepatitis C virus replication.Therefore,the pharmacological targeting effect of FKBP38 may be an effective strategy to intervene in different dependent processes of FKBP38,such as programmed cell death in cancer or neurodegenerative diseases.

关 键 词：FK506结合蛋白38 哺乳动物雷帕霉素靶蛋白 细胞凋亡 线粒体自噬 病毒复制 

分 类 号：G804.7[文化科学—运动人体科学]