双醛壳聚糖的制备及其对皮胶原纤维的交联作用  

Preparation of Dialdehyde Chitosan and its Application for Crosslinking Collagen Fiber

作　　者：黄婉丽 杨紫涵 王亚楠[1,2] 石碧[1,2] HUANG Wanli;YANG Zihan;WANG Yanan;SHI Bi(National Engineering Research Center of Clean Technology in Leather Industry,Sichuan University,Chengdu 610065,China;Key Laboratory of Leather Chemistry and Engineering(Sichuan University),Ministry of Education,Chengdu 610065,China)

机构地区：[1]四川大学制革清洁技术国家工程研究中心,四川成都610065 [2]四川大学皮革化学与工程教育部重点实验室,四川成都610065

出　　处：《皮革科学与工程》2021年第2期1-5,共5页Leather Science and Engineering

基　　金：国家重点研发计划项目(2017YFB0308500)。

摘　　要：用高碘酸钠氧化法制备了双醛壳聚糖(DCTS)。以高氧化度和低重均相对分子质量为评价指标,得到的较优制备条件为:壳聚糖脱乙酰度为95.1%,氧化初始pH为3.0,高碘酸钠与壳聚糖GlcN单元的物质的量比为1.1,氧化时间为6 h,氧化温度为20~25℃。将DCTS作为皮胶原纤维的交联剂,考察DCTS的氧化度对其交联性能的影响。DSC和压汞仪分析结果表明,随着DCTS氧化度的升高,皮胶原纤维的热变性温度提高,同时孔隙率降低,说明DCTS的交联作用逐渐增强。Dialdehyde chitosan(DCTS)was prepared by periodate oxidation.In terms of high oxidation degree and low weight average molecular weight,the conditions of DCTS preparation were optimized as follows.The deacetylation degree of CTS was 95.1%.The initial oxidation pH was 3.0.The mole ratio of sodium periodate to GlcN unit of CTS was 1.1.The oxidation duration was 6 h,and the temperature was 20-25℃.DCTS was then used as a crosslinker of collagen fiber.The effect of oxidation degree of DCTS on its crosslinking performance was investigated.DSC and mercury intrusion porosimetry analysis showed that the thermal denaturation temperature of collagen fiber rose with the increase of oxidation degree,and the porosity of collagen fiber was reduced accordingly.These results suggested that the crosslinking performance of DCTS was enhanced with the increased oxidation degree of DCTS.

关 键 词：双醛壳聚糖 高碘酸钠氧化 胶原纤维 交联 

分 类 号：TS521[轻工技术与工程—皮革化学与工程]