Neuregulin-1/ErbB信号通路在组织工程中作用的研究进展  

Research progress of neuregulin-1/ErbB signal pathway in tissue engineering

作　　者：李玲 葛少华 LI Ling;GE Shaohua(Department of Periodontology,School and Hospital of Stomatology,Cheeloo College of Medicine,Shandong University&Shandong Key Laboratory of Oral Tissue Regeneration&Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration,Shandong 250012,China)

机构地区：[1]山东大学齐鲁医学院口腔医学院·口腔医院牙周科,山东省口腔组织再生重点实验室,山东省口腔生物材料与组织再生工程实验室,山东济南250012

出　　处：《口腔医学》2021年第2期177-182,共6页Stomatology

基　　金：国家自然科学基金(81670993,81873716)。

摘　　要：组织工程的理想目标是利用生长因子、干细胞、支架系统维持、改善和修复受损的组织和器官。神经调节蛋白-1 (neuregulin-1, NRG-1)是一种内源性的生长因子,酪氨酸激酶受体(receptor tyrosine kinases, ErbB)是其发挥作用的重要受体。在神经、心血管等系统中NRG-1与ErbB结合可以激活一系列信号通路促进细胞增殖、迁移、抗凋亡和诱导多能干细胞定向分化,有助于神经和心血管组织的再生。该文就NRG-1/ErbB在组织工程中的作用和机制作一综述,从而为组织工程的发展及再生医学的临床转化提供参考。The ideal of tissue engineering is to maintain, improve, repair damaged tissues and organs with growth factors, stem cells and scaffold. Neuregulin-1(NRG-1) is an endogenous growth factor which exerts roles through its receptor tyrosine kinases(ErbB). Combining NRG-1 with ErbB in nerve and cardiovascular systems can activate a series of signal pathways to promote cell proliferation, migration, anti-apoptosis and directional differentiation of induced pluripotent stem cells, which is conducive to regeneration of nerve and cardiovascular tissues. Therefore, this paper elucidated the role and mechanism of NRG-1/ErbB in tissue engineering in order to provide theoretical basis for the development of tissue engineering and the clinical transformation of regenerative medicine.

关 键 词：神经调节蛋白-1 酪氨酸激酶受体 信号通路 组织工程 

分 类 号：Q28[生物学—细胞生物学]